Inflammasomes: mechanism of action, role in disease, and therapeutics
Abstract
The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins. They have been implicated in a host of inflammatory disorders. Recent developments have greatly enhanced our understanding of the molecular mechanisms by which different inflammasomes are activated. Additionally, increasing evidence in mouse...
Paper Details
Title
Inflammasomes: mechanism of action, role in disease, and therapeutics
Published Date
Jun 29, 2015
Journal
Volume
21
Issue
7
Pages
677 - 687
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Notes
History