Intravoxel incoherent motion diffusion-weighted MR imaging of breast cancer at 3.0 tesla: Comparison of different curve-fitting methods

Background To compare three different curve-fitting methods for intravoxel incoherent motion (IVIM) analysis in breast cancer. Methods Diffusion-weighted imaging was acquired in 30 patients with breast cancer using seven b-values (0–800 s/mm2). Three curve-fitting methods were used for biexponential IVIM analysis: a. Direct estimation of D (diffusion coefficient), D* (pseudodiffusion coefficient) and f (perfusion fraction) (Method 1), b....