Secreted IL-1α promotes T-cell activation and expansion of CD11b+Gr1+cells in carbon tetrachloride-induced liver injury in mice

Volume: 45, Issue: 7, Pages: 2084 - 2098
Published: Apr 29, 2015
Abstract
Interleukin-1α is mainly expressed on the cell membrane, but can also be secreted during inflammation. The roles of secreted and membrane IL-1α in acute liver inflammation are still not known. Here, we examined the functions of secreted and membrane IL-1α in a mouse model of carbon tetrachloride-induced acute liver injury. We show that secreted IL-1α aggravates liver damage and membrane IL-1α slightly protects mice from liver injury. Further...
Paper Details
Title
Secreted IL-1α promotes T-cell activation and expansion of CD11b+Gr1+cells in carbon tetrachloride-induced liver injury in mice
Published Date
Apr 29, 2015
Volume
45
Issue
7
Pages
2084 - 2098
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