Expression of claudin-2 in the multistage process of gastric carcinogenesis.

Claudin-2 is an important component of the tight junction (TJ) of epithelial cells, and its protein expression between many tumours is significantly different. It is unclear if Claudin-2 overexpression is a trigger or a consequence during carcinogenesis. The multistage tissues of gastric carcinogenesis provides us a valuable model for determining tumourigenicity.This paper investigated, for the first time, claudin-2 expression in the...