Irritating channels: the case of TRPA1
Abstract
Transient receptor potential (TRP) channels have been extensively studied over the past years. Yet, in most cases, the gating mechanisms of these polymodal cation channels still remain a puzzle. Using the nociceptive channel TRPA1 as an example, we discuss the role of dynamic regulation of the pore size (pore dilatation) on channel gating. Additionally, we critically revise current knowledge of the role of intracellular domains, such as ankyrin...
Paper Details
Title
Irritating channels: the case of TRPA1
Published Date
Mar 30, 2011
Journal
Volume
589
Issue
7
Pages
1543 - 1549
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