Is there a Role of Intracellular Magnesium in Prevention of Heart Failure?

Heart failure, characterized by the reduction in left and /or right ventricular function, is the most common cause of mortality and morbidity in almost around the world. This syndrome is induced by β1-adrenergic receptor (β1-AR) desensitization, which in turn is caused by the reduction in cellular cAMP concentration. Cellular cAMP concentration is modulated by adenylyl cyclases (ACs), a family of enzymes that are strongly activated by...