Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
Abstract
Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that limits vessel density in normal tissues and curtails tumor growth. Here, we show that the inhibition of angiogenesis in vitro and in vivo null and the induction of apoptosis by thrombospondin-1 all required the sequential activation of CD36, p59fyn, caspase-3 like proteases and p38 mitogen-activated protein kinases. We also detected increased endothelial cell...
Paper Details
Title
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
Published Date
Jan 1, 2000
Journal
Volume
6
Issue
1
Pages
41 - 48
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