Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients
Abstract
Rheumatoid arthritis synovial fibroblasts (RA-SFs) show an aggressive phenotype and support joint inflammation and tissue destruction. New druggable targets in RA-SFs would therefore be of high therapeutic interest. The present study shows that the intermediate-conductance, calcium-activated potassium channel KCa3.1 (KCNN4) is expressed at the mRNA and protein level in RA-SFs, is functionally active, and has a regulatory impact on cell...
Paper Details
Title
Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients
Published Date
Mar 27, 2015
Volume
230
Issue
7
Pages
1677 - 1688
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