Transient Receptor Potential Ankyrin 1 Receptor Stimulation by Hydrogen Peroxide Is Critical to Trigger Pain During Monosodium Urate–Induced Inflammation in Rodents

Objective Gout is a common cause of inflammatory arthritis and is provoked by the accumulation of monosodium urate (MSU) crystals. However, the underlying mechanisms of the pain associated with acute attacks of gout are poorly understood. The aim of this study was to evaluate the role of transient receptor potential ankyrin 1 (TRPA‐1) and TRPA‐1 stimulants, such as H 2 O 2 , in a rodent model of MSU‐induced inflammation. Methods MSU or H 2 O 2...