International textbook of diabetes mellitus

Published on Dec 5, 2015
Ralph A. DeFronzo181
Estimated H-index: 181
(University of Texas Health Science Center at San Antonio),
Ele Ferrannini112
Estimated H-index: 112
(UniPi: University of Pisa)
+ 1 AuthorsPaul Zimmet143
Estimated H-index: 143
(Alfred Hospital)
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Abstract
Diagnosis, Epidemiology and Aetiology of Diabetes Biochemistry and Pathophysiology of Diabetes Management of Diabetes Monitoring of Therapy Special Problems in Management Acute Disturbances of Diabetes Chronic Complications of Diabetes Diabetes and Public Health.
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Diabetes is a chronic disease that affects a high percentage of the world population and produces different and serious complications to patients. Most diabetes complications may be avoided by controlling the blood glucose levels exhaustively. Moreover, a prediction of future glucose levels has shown to be fundamental in helping patients to plan and modify their treatment in real-time. In this paper, a glucose predictor based on long short-term memory neural networks is designed. Three input par...
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An ecofriendly effective synthetic reaction pathway has been developed for the synthesis of phosphoramidates under mild reaction conditions. This is a green procedure and can be used in drug discov...
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To shed light on how acute exercise affects blood glucose (BG) concentrations in nondiabetic subjects, we develop a physiological pharmacokinetic/pharmacodynamic model of postprandial glucose dynamics during exercise. We unify several concepts of exercise physiology to derive a multiscale model that includes three important effects of exercise on glucose dynamics: increased endogenous glucose production (EGP), increased glucose uptake in skeletal muscle (SM), and increased glucose delivery to SM...
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Gegen Qinlian Decoction (GQD), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of common metabolic diseases, including type 2 diabetes mellitus. However, the main limitation of its wider application is ingredient complexity of this formula. Thus, it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action. Here, we compared the effects of GQD and berberine, a hypothetical key active pharmaceutica...
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Understanding the mechanism by which the exogenous biomolecule modulates the GLUT-4 signalling cascade along with the information on glucose metabolism is essential for finding solutions to increasing cases of diabetes and metabolic disease. This study aimed at investigating the effect of hamamelitannin on glycogen synthesis in an insulin resistance model using L6 myotubes. Glucose uptake was determined using 2-deoxy-D-[1-3H] glucose and glycogen synthesis were also estimated in L6 myotubes. The...
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While numerous techniques can be used to measure and analyze insulin secretion in isolated islets in culture, assessments of insulin secretion in vivo are typically indirect and only semiquantitative. The CpepSfGFP reporter mouse line allows the in vivo imaging of insulin secretion from individual islets after a glucose challenge, in live, anesthetized mice, addressing secretion from the pancreas as a whole. Imaging the whole pancreas at high resolution in live mice includes numerous technical c...
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