International textbook of diabetes mellitus

Published on Dec 5, 2015
Ralph A. DeFronzo181
Estimated H-index: 181
(University of Texas Health Science Center at San Antonio),
Ele Ferrannini112
Estimated H-index: 112
(UniPi: University of Pisa)
+ 1 AuthorsPaul Zimmet143
Estimated H-index: 143
(Alfred Hospital)
Diagnosis, Epidemiology and Aetiology of Diabetes Biochemistry and Pathophysiology of Diabetes Management of Diabetes Monitoring of Therapy Special Problems in Management Acute Disturbances of Diabetes Chronic Complications of Diabetes Diabetes and Public Health.
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Diabetes is a chronic disease that affects a high percentage of the world population and produces different and serious complications to patients. Most diabetes complications may be avoided by controlling the blood glucose levels exhaustively. Moreover, a prediction of future glucose levels has shown to be fundamental in helping patients to plan and modify their treatment in real-time. In this paper, a glucose predictor based on long short-term memory neural networks is designed. Three input par...
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INTRODUCTION Micro- and macrovascular complications of diabetes are leading morbidities in the world population. They are responsible not only for increased mortality but also severe disabilities, which jeopardize quality of life (e.g., blindness, walking limitations, and renal failure requiring dialysis). The new antidiabetic agents (e.g., glucagon-like peptide 1 receptor agonists and sodium-glucose cotransporter inhibitors) are increasingly recognized as breakthrough agents in the treatment of...
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#2Maheshwara Reddy Nadiveedhi (SVU: Sri Venkateswara University)H-Index: 3
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An ecofriendly effective synthetic reaction pathway has been developed for the synthesis of phosphoramidates under mild reaction conditions. This is a green procedure and can be used in drug discov...
#1Spencer Frank (University of California, Berkeley)H-Index: 2
#2Abdulrahman Jbaily (University of California, Berkeley)H-Index: 3
Last. Andrew J. Szeri (University of California, Berkeley)H-Index: 30
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To shed light on how acute exercise affects blood glucose (BG) concentrations in nondiabetic subjects, we develop a physiological pharmacokinetic/pharmacodynamic model of postprandial glucose dynamics during exercise. We unify several concepts of exercise physiology to derive a multiscale model that includes three important effects of exercise on glucose dynamics: increased endogenous glucose production (EGP), increased glucose uptake in skeletal muscle (SM), and increased glucose delivery to SM...
#1Xizhan Xu (CAS: Chinese Academy of Sciences)H-Index: 2
#2Zezheng Gao (Beijing University of Chinese Medicine)H-Index: 5
Last. Jun Wang (CAS: Chinese Academy of Sciences)H-Index: 110
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Gegen Qinlian Decoction (GQD), a traditional Chinese medicine (TCM) formula, has long been used for the treatment of common metabolic diseases, including type 2 diabetes mellitus. However, the main limitation of its wider application is ingredient complexity of this formula. Thus, it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action. Here, we compared the effects of GQD and berberine, a hypothetical key active pharmaceutica...
#2Gyorgy Eigner (Óbuda University)H-Index: 7
Last. Levente Kovács (Óbuda University)H-Index: 22
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In this study, we review recently proposed advanced methods based on various techniques in order to improve blood glucose control while avoiding an increased risk of hypoglycemia or hyperglycemia in patients with type 1 diabetes. We introduce type 1 diabetes and the artificial pancreas and provide an overview of research advances based on predictive control, statistical processes, filters, and machine learning. Common control methods have been successfully used to control blood glucose levels wh...
#2Ajay GuruH-Index: 2
Last. Jesu ArockiarajH-Index: 23
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Understanding the mechanism by which the exogenous biomolecule modulates the GLUT-4 signalling cascade along with the information on glucose metabolism is essential for finding solutions to increasing cases of diabetes and metabolic disease. This study aimed at investigating the effect of hamamelitannin on glycogen synthesis in an insulin resistance model using L6 myotubes. Glucose uptake was determined using 2-deoxy-D-[1-3H] glucose and glycogen synthesis were also estimated in L6 myotubes. The...
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#2Wai Pong Wong (Singapore Institute of Technology)H-Index: 11
Last. Bee Choo Tai (NUS: National University of Singapore)H-Index: 34
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Adult patients with diabetes mellitus (DM) represent one-fifth of all 30-day unplanned hospital readmissions but some may be preventable through continuity of care with better DM self-management. We aim to synthesize evidence concerning the association between 30-day unplanned hospital readmission and patient-related factors, insurance status, treatment and comorbidities in adult patients with DM. We searched full-text English language articles in three electronic databases (MEDLINE, Embase and ...
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#1Henriette Frikke-Schmidt (UM: University of Michigan)H-Index: 11
#2Peter Arvan (UM: University of Michigan)H-Index: 63
Last. Corentin Cras-Méneur (UM: University of Michigan)H-Index: 23
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While numerous techniques can be used to measure and analyze insulin secretion in isolated islets in culture, assessments of insulin secretion in vivo are typically indirect and only semiquantitative. The CpepSfGFP reporter mouse line allows the in vivo imaging of insulin secretion from individual islets after a glucose challenge, in live, anesthetized mice, addressing secretion from the pancreas as a whole. Imaging the whole pancreas at high resolution in live mice includes numerous technical c...
#1Bodoor W. Alabdullah (UOS: University of Sharjah)
#2Hind R. Alowais (UOS: University of Sharjah)
Last. Anwar Jarndal (UOS: University of Sharjah)H-Index: 13
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Diabetes affect many people around the world. While current treatments such as insulin injections and insulin pump devices are effective at managing diabetes, it still requires a manual effort that if not acted upon fast enough will lead to fatal results. This work designs and implements an artificial pancreas to improve the quality of life for diabetics by regulating the blood glucose levels and ease the burden of therapy for the insulin dependent. It presents a portable artificial pancreas sys...