Abstract 2605: Selective targeting of KRAS mutant cancer cells by a novel small molecule compound

We report here the molecular mechanism(s) underlying the anti-tumor activity of the novel small molecule, C1, which was previously shown by our group to trigger autophagy-associated apoptosis via a ROS-dependent manner in a variety of human cancer cell lines and primary cells derived from patients. Our results indicate the paradoxical involvement of mutant K-RAS as a specific target of this drug and its highly selective preference for cells with...