Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-long-evans-Tokushima Fatty rats

Volume: 63, Issue: 1, Pages: 35 - 42
Published: Mar 25, 2009
Abstract
We investigated the impact of olmesartan and temocapril on pancreatic islet beta-cells during the development of diabetes mellitus using Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats. Four-week-old male OLETF rats were fed standard chow (untreated:n5), or chow containing either 0.005% olmesartan(n5) or 0.01% temocapril (n5) until being sacrificed at 35 weeks of age. Pancreas sections were double-stained with anti-insulin and anti-glucagon...
Paper Details
Title
Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-long-evans-Tokushima Fatty rats
Published Date
Mar 25, 2009
Volume
63
Issue
1
Pages
35 - 42
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