Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease11Reprint requests to: Linda Lewis, 575 Anton Blvd, Suite 900, Costa Mesa, CA 92626.

Objective To compare the efficacy and safety of cyclosporin A ([CsA] 0.05% and 0.1% ophthalmic emulsions) to vehicle in patients with moderate to severe dry eye disease. Design Multicenter, randomized, double-masked, parallel-group, 6-month, vehicle-controlled. Participants A total of 877 patients with defined moderate to severe dry eye disease (292 to 293 in each treatment group). Methods Two identical clinical trials; patients were treated...