Combined treatment with diazepam and MK‐801 provide enhanced protection from tetramethylenedisulfotetramine‐induced seizures and lethality (1143.14)

The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and lethal GABAA Cl‐ channel antagonist. Although banned, TMDT is clandestinely produced, remains popular in Mainland China, and is the cause of numerous unintentional and deliberate poisonings worldwide. TMDT has features that make it a likely tool for terrorist activity. We sought to characterize the TMDT syndrome in C57BL/6 mice and explore the best modalities...