The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
Abstract
Researchers have been studying metastasis for more than 100 years, and only recently have we gained insight into the mechanisms by which metastatic cells arise from primary tumours and the reasons that certain tumour types tend to metastasize to specific organs. Stephen Paget's 1889 proposal that metastasis depends on cross-talk between selected cancer cells (the 'seeds') and specific organ microenvironments (the 'soil') still holds forth today....
Paper Details
Title
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
Published Date
Jun 1, 2003
Journal
Volume
3
Issue
6
Pages
453 - 458
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History