Modulation of Monocytic Cell Activity and Virus Susceptibility During Differentiation into Macrophages
Abstract
A major component of innate immune responses relies on monocytes and macrophages, virus infection of which will pose a particular problem for immunological defense. Consequently, the monocytic cell differentiation pathway was analyzed in terms of cellular modulations therein and their relation to monocytotropic virus infection. Differentiation was characterized by down-regulation of CD14, MHC Ags, the monocytic SWC1 marker, and p53; concomitant...
Paper Details
Title
Modulation of Monocytic Cell Activity and Virus Susceptibility During Differentiation into Macrophages
Published Date
Apr 1, 1999
Journal
Volume
162
Issue
7
Pages
3961 - 3969
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