Induction of epithelial to mesenchymal transition (EMT) by membrane type 1-Matrix metalloproteinase (MT1-MMP) is a prerequisite for cancer invasion

4356 null experimental and clinical evidence has demonstrated that MT1-MMP may serve as a master regulator of cancer dissemination. The mechanism underlying this process remains to be defined. While, recent reports on the role of MT1-MMP in cell migration and invasion in three dimensional (3D) type I collagen gels have expanded our understanding of cancer cell invasion, some of the data appear contradictory. Epithelial-to-mesenchymal transition...