Alternatively activated macrophages and impaired phagocytosis of S. aureus in chronic rhinosinusitis

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by biased Th2 inflammation and CRS without nasal polyps (CRSsNP) by a Th1 immune response. Colonization by Staphylococcus aureus is increased in CRSwNP. We aimed to determine macrophage phenotypes in nasal mucosa of CRSwNP and CRSsNP and to examine phagocytosis of S. aureus in these pathologies.Macrophage phenotyping was performed by immunohistochemical staining on nasal mucosa...