Acute Nonarteritic Anterior Ischemic Optic Neuropathy and Exposure to Phosphodiesterase Type 5 Inhibitors

Nonarteritic anterior ischemic optic neuropathy (NAION), a rare visual disorder, has been reported in men using phosphodiesterase type 5 inhibitors (PDE5i) for erectile dysfunction.We examined whether intermittent use of PDE5i is associated with acute NAION onset within approximately five half-lives following drug ingestion.One hundred two ophthalmology centers in the United States and Europe identified potential cases of NAION. An expert...