Intestinal absorption characteristics of imperialine: in vitro and in situ assessments

Imperialine is an effective compound in the traditional Chinese medicine chuanbeimu (Bulbus Fritillariae Cirrhosae) that has been used as antitussive/expectorant in a clinical setting. In this study we investigated the absorption characteristics of imperialine in intestinal segments based on an evaluation of its physicochemical properties.Caco-2 cells were used to examine uptake and transport of imperialine in vitro, and a rat in situ intestinal...