Reconstitution models to evaluate natural killer T cell function in tumor control.
Abstract
Natural killer T (NKT) cells are glycolipid-reactive T lymphocytes that function in immunosurveillance and immune regulation. However, reduced tumor control in NKT cell-deficient Jα18(-/-) mice may be confounded by an overall reduction in T-cell receptor (TCR) repertoire diversity in these animals. Mechanistic studies are also hindered by a lack of tools to target molecules specifically in NKT cells. To address these issues, we developed...
Paper Details
Title
Reconstitution models to evaluate natural killer T cell function in tumor control.
Published Date
Jan 1, 2016
Journal
Volume
94
Issue
1
Pages
90 - 100
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