Magnetic resonance functional nano-hydroxyapatite incorporated poly(caprolactone) composite scaffolds for in situ monitoring of bone tissue regeneration by MRI.

Published on Aug 18, 2014in Tissue Engineering Part A3.496
· DOI :10.1089/TEN.TEA.2014.0161
Nitya Ganesh4
Estimated H-index: 4
(AIMS: Amrita Institute of Medical Sciences and Research Centre),
Anusha Ashokan8
Estimated H-index: 8
+ 3 AuthorsShantikumar V. Nair75
Estimated H-index: 75
In this study, we have reported the incorporation of a multi-modal contrast agent based on hydroxyapatite nanocrystals, within a poly(caprolactone)(PCL) nanofibrous scaffold by electrospinning. The multifunctional hydroxyapatite nanoparticles (MF-nHAp) showed simultaneous contrast enhancement for three major molecular imaging techniques. In this article, the magnetic resonance (MR) contrast enhancement ability of the MF-nHAp was exploited for the purpose of potentially monitoring as well as for influencing tissue regeneration. These MF-nHAp containing PCL scaffolds were engineered in order to enhance the osteogenic potential as well as its MR functionality for their application in bone tissue engineering. The nano-composite scaffolds along with pristine PCL were evaluated physico-chemically and biologically in vitro, in the presence of human mesenchymal stem cells (hMSCs). The incorporation of 30–40 nm sized MF-nHAp within the nanofibers showed a substantial increase in scaffold strength, protein adsorpti...
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