Effect of integrin receptor-targeted liposomal paclitaxel for hepatocellular carcinoma targeting and therapy
Abstract
The major aim of the present study was to develop an integrin receptor-targeted liposomal paclitaxel (PTX) to enhance the targeting specificity and therapeutic effect of PTX on hepatocellular carcinoma (HCC) cells. The specific Arg-Gly-Asp (RGD) ligand was conjugated to 1,2-distearoylphosphatidylethanolamine-polyethylene glycol 2000 to prepare the RGD-modified liposomes (RGD-LP). Furthermore, physicochemical characteristics of RGD-LP, including...
Paper Details
Title
Effect of integrin receptor-targeted liposomal paclitaxel for hepatocellular carcinoma targeting and therapy
Published Date
May 20, 2015
Journal
Volume
10
Issue
1
Pages
77 - 84
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