AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization.
Abstract
Adeno-associated viral (AAV) vectors have been used to express several different proteins in the eye. The purpose of this study was to determine whether AAV-mediated intraocular gene transfer of pigment epithelium-derived factor (PEDF) inhibits the development of choroidal neovascularization (CNV) in a murine model.C57BL/6 mice were given intravitreous or subretinal injections of a PEDF expression construct packaged in an AAV vector (AAV-chicken...
Paper Details
Title
AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularization.
Published Date
Jun 1, 2002
Journal
Volume
43
Issue
6
Pages
1994 - 2000
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Notes
History