Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic β-cell function

Published on Jan 5, 2005in Nutrition & Metabolism3.211
· DOI :10.1186/1743-7075-2-1
Zahra Fatehi-Hassanabad12
Estimated H-index: 12
(UPEI: University of Prince Edward Island),
Catherine B. Chan36
Estimated H-index: 36
(UPEI: University of Prince Edward Island)
Background Optimal pancreatic β-cell function is essential for the regulation of glucose homeostasis in both humans and animals and its impairment leads to the development of diabetes. Type 2 diabetes is a polygenic disease aggravated by environmental factors such as low physical activity or a hypercaloric high-fat diet.
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