Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device.

To determine the safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained drug delivery device.Nonbiodegradable drug delivery devices containing 2 or 15 mg of a synthetic corticosteroid, fluocinolone acetonide, were constructed. The long-term in vitro release rates of these devices were determined in protein-free buffer or buffer containing 50% plasma protein. Fifteen-milligram devices were also implanted into the vitreous...