Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8 + T-cell responses and prevent tumour progression
Abstract
The lipid antigen α-galactosylceramide (α-GalCer) is a potent activator of invariant natural killer T-cells (iNKT cells) and can stimulate cytotoxic and anti-tumour immune responses. However optimal responses appear to be induced by α-GalCer when cell-based vaccines are delivered intravenously. Here we investigated if co-delivery of protein and peptide antigens along with α-GalCer in a liposomal formulation could stimulate therapeutic...
Paper Details
Title
Synthetic TRP2 long-peptide and α-galactosylceramide formulated into cationic liposomes elicit CD8 + T-cell responses and prevent tumour progression
Published Date
Oct 1, 2015
Journal
Volume
33
Issue
43
Pages
5838 - 5844
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