17β-Estradiol modulates huntingtin levels in rat tissues and in human neuroblastoma cell line
Abstract
17β-Estradiol (E2) exerts neurotrophic and neuroprotective functions in the brain. Here, E2-induced increased levels of huntingtin (HTT), a protein involved in several crucial neuronal functions is reported. E2 physiological concentrations up-regulate HTT in hippocampus and striatum of rats as well as in human neuroblastoma cells. This effect requires both nuclear and extra-nuclear estrogen receptor (ER)α activities. Intriguingly, HTT silencing...
Paper Details
Title
17β-Estradiol modulates huntingtin levels in rat tissues and in human neuroblastoma cell line
Published Date
Feb 1, 2016
Journal
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