Enhanced solubility and dissolution of curcumin by a hydrophilic polymer solid dispersion and its insilico molecular modeling studies

Curcumin (CUR) is highly lipophilic drug that shows degradation at alkaline pH which restricts its oral bioavailability. The aim of the present study was to enhance the oral bioavailability of CUR by increasing its solubility and dissolution rate. Solid dispersions (SDs) of CUR in aqueous and organic solvent using Eudragit EPO (EuD) were prepared by spray drying and rota evaporation technique. The solubility of plain CUR in acidic pH 1.2 is only...