Clinical Correlates and Neural Substrates of P50 Suppression Deficits in Schizophrenia

The present dissertation evaluated the P50 component of the event-related brain potential (ERP), an index of sensory gating measured during a paired-stimulus paradigm, as an intermediate phenotype between clinical symptoms and neuronal mechanisms that might also contribute to higher-order cognitive dysfunction in schizophrenia. Despite considerable evidence that schizophrenia patients exhibit impaired suppression of the P50 to the second of two...