Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice
Abstract
Angiogenesis is essential for tissue development, wound healing and tissue perfusion, with its dysregulation linked to tumorigenesis, rheumatoid arthritis and heart disease. Here we show that pro-angiogenic stimuli couple to NADPH oxidase-dependent generation of oxidants that catalyse an activating intermolecular-disulphide between regulatory-RIα subunits of protein kinase A (PKA), which stimulates PKA-dependent ERK signalling. This is crucial...
Paper Details
Title
Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice
Published Date
Aug 10, 2015
Journal
Volume
6
Issue
1
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