Cytotoxic polyprenylated acylphloroglucinol derivatives from Hypericum henryi

Published on Oct 28, 2015in Tetrahedron2.233
· DOI :10.1016/J.TET.2015.08.059
Jing-Jing Zhang9
Estimated H-index: 9
(CAS: Chinese Academy of Sciences),
Xing-Wei Yang17
Estimated H-index: 17
(CAS: Chinese Academy of Sciences)
+ 3 AuthorsGang Xu36
Estimated H-index: 36
(CAS: Chinese Academy of Sciences)
Sources
Abstract
Six new dicyclic polyprenylated acylphloroglucinol derivatives, hyperhenones A-F (1-6), together with twelve known analogues, were isolated from the aerial parts of Hypericum heniyi. Their structures were elucidated based on the comprehensive MS and NMR spectroscopic data. The inhibitory activities of these isolates on four human tumor cell lines were assayed, and compounds 5, 7, and 10 showed significant inhibitory effects with the IC50 1.3-8.8 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
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