Human calprotectin is an iron-sequestering host-defense protein
Abstract
Human calprotectin (CP) is a metal-chelating antimicrobial protein of the innate immune response. The current working model states that CP sequesters manganese and zinc from pathogens. We report the discovery that CP chelates iron and deprives bacteria of this essential nutrient. Elemental analysis of CP-treated growth medium establishes that CP reduces the concentrations of manganese, iron and zinc. Microbial growth studies reveal that iron...
Paper Details
Title
Human calprotectin is an iron-sequestering host-defense protein
Published Date
Aug 24, 2015
Journal
Volume
11
Issue
10
Pages
765 - 771
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