A breakthrough novel method to resolve the drug and target interference problem in immunogenicity assays
Abstract
Biological matrix interference in detection and quantitation immunoassays remains a major challenge in the field of bioanalysis. For example, circulating drug may interfere with the detection of anti-drug antibodies (ADA) and drug target, or ADA may interfere with quantitation of drug levels in PK/TK analysis. Monoclonal antibody drug interference, especially for human IgG4 drugs, presents an additional challenge for ADA analysis due to its...
Paper Details
Title
A breakthrough novel method to resolve the drug and target interference problem in immunogenicity assays
Published Date
Nov 1, 2015
Volume
426
Pages
62 - 69
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