Neoplasma
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#1Na Shan (WMU: Wenzhou Medical College)
#2Leyi Ni (WMU: Wenzhou Medical College)H-Index: 1
Last. Zhenzhai Cai (WMU: Wenzhou Medical College)H-Index: 2
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Pancreatic ductal adenocarcinoma is a complex gastrointestinal tumor with high metastatic potential and poor prognosis. Actin-binding protein Girdin is highly expressed in a variety of tumors and promotes tumor genesis and progression. However, the mechanisms underlying the involvement of Girdin in pancreatic cancer have not been clarified. In this study, we observed that the expression of Girdin was upregulated in pancreatic cancer cells. The siRNA-mediated gene knockdown experiments showed tha...
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#1Hongyue Zhao (HMU: Harbin Medical University)
#2Ye-Xin Su (HMU: Harbin Medical University)
Last. Peng Fu (HMU: Harbin Medical University)
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The aim of this study was to build a prediction model for epidermal growth factor receptor (EGFR) mutations in lung adenocarcinoma. A retrospective analysis was performed on 88 patients with lung adenocarcinoma. All patients underwent an 18F-FDG PET/CT scan and genetic testing of EGFR before the treatment. In the training set, the radiomics features and clinical factors were screened out, and model1 based on CT radiomics features, model2 based on PET radiomics features, model3 based on clinical ...
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#1Yi-Xin Su (Peking Union Medical College)H-Index: 1
#2Cheng-Feng Yu (Peking Union Medical College)
Last. Shijie Zhu (Peking Union Medical College)H-Index: 2
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Prostate cancer (PCa) is one of the most common malignancies in men worldwide, and metastatic castrate-resistant prostate cancer (mCRPC) has shown a poor prognosis. Although chemotherapy and androgen deprivation therapy (ADT) have improved clinical outcomes, the median survival (MS) of patients with mCRPC is still less than 2 years. With the development of poly adenosine diphosphate-ribose polymerase inhibitor (PARPi), the treatment strategy for patients with mCRPC has markedly evolved. Olaparib...
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#1Dian-Qi Li (HUST: Huazhong University of Science and Technology)
#2Ci-Cheng Huang (HUST: Huazhong University of Science and Technology)
Last. Lei-Lei Zhou (HUST: Huazhong University of Science and Technology)
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N6-methyladenosine (m6A) is the most common internal reversible modification of mRNA, which occurs on the N6 nitrogen of adenosine. Fat mass and obesity-associated (FTO) is a demethylase that erases m6A modification and has recently been linked to cancer. Herein, we explored the role of FTO in oral squamous cell carcinoma (OSCC). High FTO mRNA and protein levels were observed in OSCC cell lines and tissues as compared to normal controls. OSCC patients with high FTO displayed larger tumor size, h...
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#1Lydia Usha (Rush University Medical Center)H-Index: 8
#2Oleksandra Klapko (Rush University Medical Center)H-Index: 2
Last. Seby L. Edassery (Rush University Medical Center)H-Index: 12
view all 3 authors...
Cell-based therapies cure some hematologic malignancies, although little information exists on solid cancer cell responses. The study objective was to test the hypothesis that xenogeneic fibroblasts can inhibit the growth of human cancer cell lines in vitro. Seven human cell lines (pancreatic cancer HPAF II; brain cancer U-87 MG; fibrosarcoma; ovarian cancer OVCAR3 and SKOV3; and breast cancer MCF7 and MDA-MB231) were co-cultured with two xenogeneic fibroblast cell lines (CV-1; monkey, Cercopith...
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#1Keyan Wu (YZU: Yangzhou University)H-Index: 8
#2Hua Xie (YZU: Yangzhou University)
Last. Weigan Shen (YZU: Yangzhou University)H-Index: 9
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Emerin (EMD) plays diverse roles in cellular polarity organization, nuclear stability, and cell motility, however, the biological role of EMD relevant to the migration and invasion of hepatocellular carcinoma (HCC) cells has not yet been illustrated. In the present study, we initially found that the upregulation of EMD in HCC tissues, and EMD expression was negatively correlated with the spontaneous metastatic potential of HCC cell lines. Loss of EMD in HCC cells facilitated cell migration and i...
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#1Yuanlin LiuH-Index: 1
#2Shuting Gu (Nantong University)H-Index: 1
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Recently, change in the GNG13 expression has been shown to result in multiple congenital malformations and sexual reversal, and it was also found in the brain. The aim of this study was to measure the expression levels in epithelial ovarian cancer (EOC) and breast cancer (BC) and assess their value as a potential prognostic marker. The correlation of GNG13 protein expression was detected by immunohistochemistry (IHC) in 119 EOC and 125 BC tissues. Assessment of the associations between GNG13 lev...
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#1Mohamed Hussam Aswad (Masaryk University)H-Index: 1
#2Jarmila Kissová (Masaryk University)H-Index: 8
Last. Miroslav Penka (Masaryk University)H-Index: 19
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Thrombosis is the most common complication in BCR-ABL1 negative myeloproliferative neoplasms (MPN) that significantly impacts patients' mortality. Generally, there is an agreement on risk factors that possibly contribute to the increased risk of thrombosis, including age, history of thrombosis, JAK2V617F mutation, and cardiovascular risk factors. This study retrospectively investigates MPN-related and patient-related variables in relation to the thrombosis occurrence in MPN. Our analyses show th...
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Papillary thyroid carcinoma (PTC) is the most prevalent form of thyroid cancer (TC). There is increasing evidence that circular RNAs play a role in the tumorigenesis of PTC. The aim of our study was to evaluate the potential function of circ_0067934 in PTC and the underlying molecular mechanism. In our study, cell viability assay, quantitative real-time PCR (qRT-PCR), colony formation assay, flow cytometry, wound-healing assay, Transwell invasion assay, western blot, soft agar assay, RNA immunop...
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#1Yun-Long Cui (TMUCIH: Tianjin Medical University Cancer Institute and Hospital)H-Index: 1
Last. Pengfei Liu (LNUTCM: Liaoning University of Traditional Chinese Medicine)H-Index: 2
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The purpose of this study was to identify gene mutations, high frequency mutations, and driver genes in liver cancer, and the marketed approved drugs of these genes, to provide evidence for targeted treatment of liver cancer since it is one of the most common cancers worldwide. 34 patients with liver cancer were included, and their blood samples were collected. The pathway enrichment analysis of the mutation gene was carried out through the KEGG database, and the genes with marketed approved dru...
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