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#1Ömer Bayır (UHSA: University of Health Sciences Antigua)H-Index: 7
#2Gökhan Toptaş (UHSA: University of Health Sciences Antigua)H-Index: 1
Last. Mehmet Hakan Korkmaz (UHSA: University of Health Sciences Antigua)H-Index: 9
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OBJECTIVE To reveal the incidence and predictive parameters of occult cervical lymph node metastasis (LNM) in patients with cN0 laryngeal squamous cell cancer (LSCC) who underwent surgery as definitive treatment. METHODS Patients with cN0 laryngeal cancer who had undergone elective neck dissection together with partial or total laryngectomy between January 2006 and November 2020 were retrospectively analyzed. Clinical and histopathologic predictors of occult metastasis were also analyzed. Follow...
#1Carla Ripamonti (University of Milan)H-Index: 61
#2Giacomo Massa (University of Milan)H-Index: 5
Last. Francesco Pagnini (UCSC: Catholic University of the Sacred Heart)H-Index: 22
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Aim:To understand how patients with cancer reacted to the coronavirus disease 2019 (COVID-19) pandemic and whether their quality of life (QoL) was affected.Methods:In June 2020, 111 patients with c...
#1Gianpiero FasolaH-Index: 18
#2Maria Carla Barducci (Bocconi University)
Last. Giordano D. BerettaH-Index: 22
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Oncology is going through the fastest innovation period in the history of medicine and a growing number of patients improve or experience increased chances of survival. The declining death rate, starting from 1991, resulted in 2.9 million deaths avoided in the United States so far. A growing prevalence of patients is observed in all Western countries. New cancer drug approvals between 2000 and 2016, linked to other diagnostic, surgical, and health care improvements, were significantly associated...
#1Fengbo Zhao (Nantong University)H-Index: 6
#2Aifen Liu (Nantong University)H-Index: 1
Last. Renfang Mao (Nantong University)H-Index: 16
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Background:Hypoxia is a hallmark of solid cancers, including hepatocellular carcinoma (HCC). There is scarce information about how hypoxia avoids immunologic stress and maintains a cancer-promoting...
#1Ginevra LolliH-Index: 3
#2Beatrice Casadei (UNIBO: University of Bologna)H-Index: 11
Last. Pier Luigi Zinzani (UNIBO: University of Bologna)H-Index: 105
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OBJECTIVE Peripheral T-cell lymphomas (PTCLs) are a group of heterogeneous T-cell malignancies representing 5%-10% of aggressive lymphomas. The prognosis is poor for patients with relapsed/refractory (R/R) disease, with a median overall survival of less than 6 months and no standardized treatments. We discuss the role of the phosphatidylinositol 3-kinase (PI3K) γδ inhibitor duvelisib as bridge to allotransplantation in a patient with R/R PTCL. METHODS Case report. RESULTS A 55-year-old woman dia...
#1Paolo Borghetti (University of Brescia)H-Index: 11
#2Jessica Imbrescia (University of Brescia)H-Index: 1
Last. Davide Tomasini (University of Brescia)H-Index: 4
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BACKGROUND Standard treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is concomitant chemoradiotherapy. The survival benefit of combined treatment is partially counterbalanced by an increased rate of acute esophageal toxicity. Several pharmaceutical products are available for prevention and management of esophagitis, including Faringel Plus. AIM To assess the incidence and the grade, identify the correlations with clinical, dosimetric, and therapeutic variables, and analyse th...
Drug-drug interactions represent a topic of great interest, not only due to the risk of unexpected adverse events but also due to the possibility of altering the effectiveness of a specific treatment. Inappropriate or concomitant use of drugs can often lead to changes in the bioavailability of various compounds, resulting in pharmacokinetic alterations. A recent example is the concomitant administration of proton pump inhibitors (PPIs) and anticancer agents. PPIs are overused beyond their classi...
#1Andrea Billè (Guy's Hospital)H-Index: 13
#2Rajdeep Bilkhu (Guy's Hospital)H-Index: 1
Last. Gianluca Lucchese (Guy's Hospital)
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BACKGROUND: For stage III or IVa thymic tumours, a multimodality approach is recommended. The role of surgery is to achieve complete resection. AIM: To present the outcomes of patients undergoing surgery for stage III or IVa thymoma. METHODS: Retrospective review of patients undergoing open surgery for stage III or IVa thymoma between 2016 and 2020 at a single centre was performed. Preoperative imaging, treatment plan, surgical approach, and postoperative outcomes were analyzed. RESULTS: Forty-s...
#1Sarabjot Singh-Makkar (Larkin Community Hospital)H-Index: 1
#2Krunal Pandav (Larkin Community Hospital)H-Index: 2
Last. Pamela Youssef (UM: University of Miami)
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Metformin has been in clinical use for more than half a century, yet its molecular mechanism of action is not entirely understood. Metformin has been shown to have antiproliferative and synergistic effects on various types of cancers. The anticancer effects of metformin are potentially applicable to both diabetic and nondiabetic patients. Areas of ongoing investigation focus on metformin's ability to activate adenosine monophosphate kinase (AMPK), in addition to its effect on Myc mRNA, monocarbo...
#1Carmine GuarinoH-Index: 2
#2Cristiano CesaroH-Index: 1
Last. Enzo ZamparelliH-Index: 1
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Malignant central airway obstruction is a life-threatening condition that often causes respiratory failure. In many cases, treatment of tumor in rigid bronchoscopy must be performed urgently, soothing respiratory symptoms and improving patient quality of life, in many cases reducing time to and allowing application of oncologic therapies. Immuno-oncologic therapies target the immune system selectively and are therefore much less toxic than standard chemotherapies, sometimes leading to outstandin...
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Molecular biology