Molecular Therapy - Oncolytics
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#1Martí Farrera-SalH-Index: 4
#2Rafael MorenoH-Index: 11
Last. Ramon AlemanyH-Index: 21
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Abstract null null Oncolytic viruses (OVs) preferentially infect and selectively replicate in cancer cells. OVs have been tested in clinical trials as monotherapy or in combination with chemotherapy, radiotherapy, and immunotherapy. However, the dense extracellular matrix hampers the intratumoral spreading and efficacy of OVs. Previously we described VCN-01, an oncolytic adenovirus expressing a soluble version of human sperm hyaluronidase PH20, which exhibited enhanced intratumoral distribution ...
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#1Nuttavut Sumransub (UMN: University of Minnesota)
#2Kornpong Vantanasiri (UMN: University of Minnesota)H-Index: 3
Last. Emil Lou (UMN: University of Minnesota)H-Index: 27
view all 4 authors...
Abstract Immunotherapy in the metastatic setting has drastically altered the landscape of treatment for various types of malignancy, including colorectal cancer. The category of immune checkpoint inhibitors has especially emerged as a class of therapy predicated on a more comprehensive understanding of immune cell-cancer cell regulation and evolution of the tumor microenvironment over time. Strategies including adoptive cellular therapies, tumor vaccines, and antibodies have also demonstrated ab...
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#1Y.R. Suryawanshi (Mayo Clinic)
#2Rebecca Nace (Mayo Clinic)H-Index: 13
Last. Autumn J. Schulze (Mayo Clinic)H-Index: 2
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Abstract null A dual microRNA-detargeted oncolytic Mengovirus, vMC24NC, proved highly effective against a murine plasmacytoma in an immunocompetent syngeneic mouse model, however there remains the concern of escape mutant development and the potential for toxicity in severely immune compromised cancer patients when used as an oncolytic virus. Therefore, we sought to compare the safety and efficacy profiles of an attenuated Mengovirus containing a virulence gene deletion versus vMC24NC in an immu...
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#1Koichi Kitagawa (Kobe University)H-Index: 9
#2Maho Tatsumi (Kobe University)H-Index: 1
Last. Toshiro Shirakawa (Kobe University)H-Index: 31
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Abstract null Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) such as PD-1/PD-L1 inhibitors has been well established for various types of cancer. Monotherapy with ICIs, however, can achieve a durable response in only a subset of patients. There is a great unmet need for the ICI-resistant-tumors. Since patients who respond to ICIs should have preexisting antitumor T cell response, combining ICIs with cancer vaccines which forcibly induce an antitumor T cell response is a reasonabl...
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#1Vivian Weiwen Xue (CUHK: The Chinese University of Hong Kong)H-Index: 4
#2Jeff Yat-Fai Chung (CUHK: The Chinese University of Hong Kong)H-Index: 4
Last. Ka Fai To (CUHK: The Chinese University of Hong Kong)H-Index: 90
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Abstract null Mincle is essential for tumour-associated macrophage (TAM)-driven cancer progression, and represents a potential immunotherapeutic target for cancer. Nevertheless, a lack of specific inhibitor has largely limited its clinical translation. Here, we successfully developed a gene therapeutic strategy for silencing Mincle in a virus-free and tumour-specific manner by combining the RNA interference technology with ultrasound-microbubble-mediated gene transfer system (USMB). We identifie...
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#1Charles Shin (Kyung Hee University)
#2Sungsoo S. Kim (Kyung Hee University)H-Index: 56
Last. Yong Hwa Jo (Kyung Hee University)H-Index: 10
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ABSTRACT null null Immunotherapy has been well regarded as one of the safer and antigen-specific anticancer treatments compared to first-generation chemotherapy. Since Coley’s discovery, researchers focused on engineering novel antibody-based therapies. Including artificial and modified antibodies, such as antibody fragments, antibody-drug conjugates, and synthetic mimetics, the variety of immunotherapy has been rapidly expanding in the last few decades. Genetic and chemical modifications to mon...
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#1Xiaoyu Chao (Henan University)H-Index: 1
#2Pei Wang (Henan University)
Last. Yaowu Du (Henan University)H-Index: 1
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Abstract null null Clear cell renal cell carcinoma (ccRCC) is the most common histological type of renal carcinoma, and has a high recurrence rate and poor outcome. Accurate patients risk stratification based on genetic markers can help to identify the high risk patient for early and further treatments and would promote the patient survival. Long non-coding RNAs (lncRNAs) have attracted widespread attentions as biomarkers for early diagnosis, treatment and prognosis due to their high specificity...
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#1Sanxiu HeH-Index: 2
#2Shaorong TianH-Index: 2
Last. Qin Xiang (CQMU: Chongqing Medical University)H-Index: 6
view all 13 authors...
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#2You-Zuo Chen (ISU: I-Shou University)
Last. Ya-Ting TuH-Index: 1
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Abstract null Long noncoding RNAs (lncRNAs) are a group of nonprotein coding transcripts that play a critical role in cancer progression. However, the role of lncRNA in metformin-induced inhibition of cell growth and its biological function in gastric cancer remain largely unknown. In this study, we identified an oncogenic lncRNA, Loc100506691, the expression of which was decreased in gastric cancer cells with metformin treatment. Moreover, Loc100506691 was significantly overexpressed in gastric...
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#1Tatsuya Deguchi (Hokkaido University)H-Index: 2
#2Kenji Hosoya (Hokkaido University)H-Index: 7
Last. Mahiro Okumura (Hokkaido University)
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Abstract null null Metformin has many anti-cancer effects, alone or in combination with radiation. However, the mechanism underlying its radio-sensitized effect is still unclear, especially for cancer stem-like cells (CSCs). Here, the radio-sensitized effect of metformin was investigated, and its mechanism was revealed in CSCs derived from HMPOS, a canine osteosarcoma cell line. Spheroid cells (SCs) were used as a CSCs rich cells derived from sphere formation and SCs were compared with normal ad...
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Top fields of study
Cancer
Virus
Cancer research
Medicine
Oncolytic virus
Biology