The International Journal of Mycobacteriology
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Papers 1,032
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Background: To date, there have been no reports on the occurrence of nontuberculous mycobacterial (NTM) organisms (nor tuberculosis [TB]) on money, currency, banknotes, or coins, where these may act as fomites in the potential transmission of mycobacterial organisms around communities, especially in developing nations, where physical currency is still the popular mainstay of the economy, compared to electronic and digital forms of currency transaction. It was therefore the aim of this study to e...
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#1Priyanka (Miranda House, University of Delhi)
#2Monika Sharma (Miranda House, University of Delhi)H-Index: 8
Last. Sadhna Sharma (Miranda House, University of Delhi)H-Index: 2
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Background: Host genetic background plays an important role in susceptibility to intracellular infectious pathogens like Mycobacterium tuberculosis (Mtb). Cellular immune response activation is vital for protection to these pathogens. Interferon-gamma (IFN-γ) plays a crucial role in this activation and preventing the intracellular growth of Mtb. A mutation in the IFN-γ gene, therefore, may lead to increased susceptibility to tuberculosis (TB) that may vary in different ethnic groups and its cons...
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Background: The association between diabetes mellitus (DM) and tuberculosis (TB) and their synergistic role in causing human disease has been recognized for centuries. Despite the known synergy between DM and TB, the importance of atypical clinical, radiological presentation and DM as a risk factor for TB is largely unknown. This study was undertaken to know the effect of glycemic control on TB manifestations as it will contribute to the opportunities for detection and treatment of both disease ...
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Background: Tuberculosis (TB) is a disease that mainly affects human lungs. It can be fatal if the treatment is delayed. This study investigates the prediction of treatment failure of TB patients focusing on the features which contributes mostly for drug resistance. Methods: Support vector machine (SVM) is a relatively novel classification model that has shown promising performance in regression applications. Genetic algorithm (GA) is a method for solving the optimization problems. We have consi...
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#1John E. Moore (Belfast City Hospital)H-Index: 61
#2M. SmythH-Index: 2
Last. Beverley C. Millar (Belfast City Hospital)H-Index: 15
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#1Foluke Adenike Ayeni (University of Lagos)
#2Olubukola O. Oyetunde (University of Lagos)H-Index: 3
Last. Bolajoko A. Aina (University of Lagos)H-Index: 7
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Background The burdens of tuberculosis (TB) and diabetes mellitus (DM) in Nigeria are high. DM often goes unrecognized in TB patients, resulting in poorer treatment outcomes compared with TB patients only. This study set out to compare TB treatment outcomes and associated factors in TB only and TBDM patients when a collaborative care (CC) model is in place. Methods A prospective quasi-experimental study, modeled after the World Health Organization and The Union's Collaborative Framework for Care...
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#1Yeimer Ortiz-Martínez (UIS: Industrial University of Santander)H-Index: 6
#2Javier Enrique Fajardo-Rivero (UIS: Industrial University of Santander)H-Index: 2
Last. Alfonso J. Rodriguez-Morales (Scientific University of the South)H-Index: 66
view all 7 authors...
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#1Nurul Wiqoyah (UNAIR: Airlangga University)H-Index: 1
#2Ni Made Mertaniasih (UNAIR: Airlangga University)H-Index: 7
Last. Sohkichi Matsumoto (UNAIR: Airlangga University)H-Index: 1
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Background Cases of tuberculosis (TB) and multidrug-resistant TB (MDR-TB) in South-east Asia including Indonesia are still high. The presence of mixed infections in TB cases has been reported. Several studies revealed the role of the human microbiome in TB. This study purposes to characterize microbiome which can be a potential biomarker of chronicity in TB or MDR-TB. Methods Sputum samples of pulmonary TB patients confirmed MDR-TB and resistant to rifampicin TB (RR-TB) were conducted Metagenomi...
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#1Chanchal Kumar (University of Delhi)H-Index: 5
#2Kamal Shrivastava (University of Delhi)H-Index: 4
Last. Mandira Varma-Basil (University of Delhi)H-Index: 15
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Background: Rapidly growing mycobacteria (RGM) are increasingly being recognized as potential pathogens. RGM, particularly Mycobacterium abscessus, Mycobacterium fortuitum, and Mycobacterium chelonae, have been observed in both pulmonary and extrapulmonary infections including cutaneous, soft-tissue, and wound infections. However, there are limited reports of these potential pathogens from skin and soft-tissue infections. Moreover, the drug susceptibility profile of RGM is largely unknown in sev...
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#1Kohei Kuriki (KIT: Kyushu Institute of Technology)
#2Junichi Taira (KIT: Kyushu Institute of Technology)H-Index: 1
Last. Shunsuke Aoki (KIT: Kyushu Institute of Technology)H-Index: 2
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Background: The emergence of frequent hitters (FHs) remains a challenge in drug discovery. We have previously used in silico structure-based drug screening (SBDS) to identify antimycobacterial candidates. However, excluding FHs has not been integrated into the SBDS system. Methods: A dataset comprising 15,000 docking score (protein–compound affinity matrix) was constructed by multiple target screening (MTS): DOCK–GOLD two-step docking simulations with 154,118 compounds versus the 30 target prote...
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