Clinical And Translational Immunology
Papers 467
1 page of 47 pages (467 results)
#1Chongxu ZhangH-Index: 7
#2Runxia TianH-Index: 8
Last. Andrew V. Schally (Veterans Health Administration)H-Index: 56
view all 11 authors...
Objectives null Growth hormone-releasing hormone (GHRH) is a potent stimulator of growth hormone (GH) secretion from the pituitary gland. Although GHRH is essential for the growth of immune cells, the regulatory effects of its antagonist in granulomatous disease remain unknown. null Methods null Here, we report expression of GHRH receptor (R) in human tissue with sarcoidosis granuloma and demonstrate the anti-inflammatory effects of MIA602 (a GHRH antagonist) in two in vitro human granuloma mode...
#1Athina Georgiadou (Imperial College London)H-Index: 5
#2Praveena Naidu (Imperial College London)
Last. Aubrey J. Cunnington (Imperial College London)H-Index: 20
view all 8 authors...
Objective Cerebral malaria (CM) is a complication of Plasmodium falciparum malaria, in which progressive brain swelling is associated with sequestration of parasites and impaired barrier function of the cerebral microvascular endothelium. To test the hypothesis that localised release of matrix metallopeptidase 8 (MMP8) within the retina is implicated in microvascular leak in CM, we examined its expression and association with extravascular fibrinogen leak in a case-control study of post-mortem r...
1 CitationsSource
Objectives Type I interferons are evolutionally conserved cytokines, with broad antimicrobial and immunoregulatory functions. Despite well-characterised role in spontaneous cancer immunosurveillance, the function of type I IFNs in cancer immunotherapy remains incompletely understood. Methods We utilised genetic mouse models to explore the role of the type I IFN system in CD8+ T-cell immunotherapy targeting the melanocytic lineage antigen gp100. Results The therapeutic efficacy of adoptively tran...
#1Tianwen Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Xiaohui Gong (SJTU: Shanghai Jiao Tong University)
Last. Yongjun Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 8
view all 10 authors...
Objectives The present phenotype-based disease classification causes ambiguity in diagnosing and determining timely, effective treatment options for primary immunodeficiency (PID). In this study, we aimed to examine the characteristics of early-onset PID and proposed a JAK-STATopathy subgroup based on their molecular defects. Methods We reviewed 72 patients (< 100 days) retrospectively. These patients exhibited various immune-related phenotypes and received a definitive molecular diagnosis by ne...
#1Yeongbeen Kwon (SMC: Samsung Medical Center)
#1Yeongbeen Kwon (SMC: Samsung Medical Center)H-Index: 1
Last. Ghee Young Kwon (SMC: Samsung Medical Center)H-Index: 20
view all 15 authors...
#1Johnna D. Wesley (Novo Nordisk)H-Index: 6
#2Susanne Pfeiffer (La Jolla Institute for Allergy and Immunology)
Last. Matthias von Herrath (Novo Nordisk)H-Index: 70
view all 8 authors...
Objectives The detection of a peripheral immune cell signature that specifically reflects autoimmunity in type 1 diabetes would enable the prediction and staging of disease on an individual basis. However, defining such a signature is technically challenging. Reliable interpretation of immune cell-related biomarkers depends on their inherent variability and, to understand this variability, longitudinal analyses are required. Methods We performed a longitudinal observational study in which 40 ind...
#1Guoli Huai (University of Electronic Science and Technology of China)
#1Guoli Huai (Harvard University)
Last. Charles G. Rickert (Harvard University)H-Index: 7
view all 4 authors...
Regulatory B cells contribute to the regulation of immune responses in cancer, autoimmune disorders, allergic conditions and inflammatory diseases. Although most studies focus on regulatory B lymphocytes expressing interleukin-10, there is growing evidence that B cells producing transforming growth factor β (TGF-β) can also regulate T-cell immunity in inflammatory diseases and promote the emergence of regulatory T cells that contribute to the induction and maintenance of natural and induced immu...
1 CitationsSource
#1Maurice Steenhuis (UvA: University of Amsterdam)H-Index: 2
#2Gerard van Mierlo (UvA: University of Amsterdam)H-Index: 14
Last. Theo Rispens (UvA: University of Amsterdam)H-Index: 49
view all 21 authors...
Abstract Objectives Characterisation of the human antibody response to SARS-CoV-2 infection is vital for serosurveillance purposes and for treatment options such as transfusion with convalescent plasma or immunoglobulin products derived from convalescent plasma In this study, we longitudinally and quantitatively analysed antibody responses in RT-PCR-positive SARS-CoV-2 convalescent adults during the first 250 days after onset of symptoms Methods We measured antibody responses to the receptor-bin...
2 CitationsSource
#1Yuna Chang (New Generation University College)H-Index: 5
#2Ju Whi Kim (New Generation University College)H-Index: 5
Last. Hyeyoung Kim (New Generation University College)H-Index: 20
view all 7 authors...
Objectives null Inflammatory bowel disease (IBD) is characterised by dysregulated mucosal immune responses associated with genetic, environmental and microbial factors. Recent therapies targeting key inflammatory mediators such as tumor necrosis factor (TNF)-α emphasise the importance of innate immunity in the development of IBD. null Methods null We examined the distribution of innate immune cells such as innate lymphoid cells (ILCs) and myeloid cells in the intestinal epithelium from children ...
#1Hyon-Xhi Tan (University of Melbourne)H-Index: 12
#2Wen Shi Lee (University of Melbourne)H-Index: 12
Last. Jennifer A. Juno (University of Melbourne)H-Index: 18
view all 21 authors...
Objectives Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T-cell memory in adults. Methods We quantified CD4 T-cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2-uninfected individuals. Antigen-specific memory T cells and circulating T follicular helper (cTFH) cells were identified using an activation-induced marker assay and characterise...
3 CitationsSource
Top fields of study
Immune system