Postepy biochemii
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#1Jakub WlodarczykH-Index: 24
Last. Jakub FichnaH-Index: 35
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Short-chain fatty acids (SCFAs) produced in the human colon are the major products of bacterial fermentation and are believed that they have a protective effect in case of gastrointestinal diseases. SCFAs, such as acetate, propionate, and butyrate are significant metabolites in intestinal homeostasis, and have been shown to be beneficial in inflammatory bowel diseases and colorectal cancer. SCFA are responsible for maintaining proper intestinal barrier and they take part in relevant immune funct...
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Last. Jerzy BalH-Index: 21
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Ectodermal dysplasias are a wide group of genetic disorders characterised by clinical symptoms in ectodermal derivatives (most frequently teeth, hair, nails and sweat glands). There is a number of genes, which, if mutated, can cause the specified phenotype. The molecular basis of many ectodermal dysplasias have been investigated. The phenotype often results from the imparied communication in molecular pathways important in embryonic morphogenesis or disturbed function of protein complexes involv...
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Photodynamic therapy (PDT) is one of the least toxic methods causing the death of cancer cells. Photosensitizer (PS) applied to a patient accumulates in the tumor, where under the appropriate wavelength and insensitivity of light is activated. Activated PS in the presence of oxygen produces reactive oxygen species (ROS), which make significant damage leading to the destruction of cancer cells by apoptosis, necrosis or autophagic process. Moreover, PDT causes an acute local inflammatory response ...
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Lysosomal acid lipase (LAL) plays a key role in lipid metabolism through the hydrolysis of cholesteryl esters and triglycerides in lysosomes. LAL deficiency is a rare autosomal recessive lysosomal storage disease caused by deleterious mutations in the LIPA gene. In the case of LAL deficiency, cholesteryl esters and triglycerides accumulate within the lysosomes. The up-regulation of endogenous cholesterol production, increased synthesis of apolipoprotein B (ApoB) and increased production of very-...
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#2Agnieszka BelterH-Index: 7
Last. Jan BarciszewskiH-Index: 32
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The year 2021 marks not only 60 years since the discovery of messenger RNA and the genetic code. Already 100 yaers passed since RNA was discovered. On the occasion of this special anniversary, we would like to recall the most important events in the history of nucleic acids that led to the above discoveries. We remind the beginning of a new era in science caused by the isolation of nuclein and then nucleic acid, whose components and properties were gradually learned, often by little-known resear...
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Plants are natural laboratories producing a cornucopia of secondary metabolites of huge therapeutic potential. The oil extracted from rice bran, a by-product of brown rice processing, is abundant in valuable bioactive substances. One of its main ingredients is gamma-oryzanol that is a mixture of phytosterol esters and ferulic acid. These compounds exert a wide range of biological activities closely correlated with their chemical properties. Their hypocholesterolemic and antioxidant abilities are...
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The aim of this article is to synthesize informations about monoamine oxidase inhibitors drugs (MAOI) used in the treatment of depression. General informations on monoamine oxidase (MAO) and its kinetic properties are presented. MAO is an enzyme that degrades catecholamines and their 3-methoxy derivatives and other monoamines, for example serotonin or tryptamine. The criteria and symptoms of depressive disorders are discussed. They have to be distinguished from the state of sadness and similar s...
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The research concerned the determination of the frequency of occurrence of selected virulence genes (cadF, flaA, iam) and genes responsible for the formation of the CDT cytotoxin (cdtA, cdtB, cdtC) in Campylobacter spp. The research object consisted of 100 faecal samples collected from stallions showing no symptoms of campylobacteriosis. The presence of bacteria of the genus Campylobacter spp. Was found in 25 individuals (25%). The molecular biology techniques used in the research allowed us to ...
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Changes in glycosylation pattern of cell surface, body fluids and extracellular matrix glycoconjugates is a characteristic feature of tumor cell malignancy. These changes are the result of mutations of tumor-associated genes as well as epigenetic changes in the tumor environment, including nutrient influx, hypoxia, cytokine expression and stimulation of chronic inflammation. The unique set of cell surface glycoantigens on neoplastic cells is recognized by endogenous lectins located in the extrac...
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#2Martyna PekalaH-Index: 1
Last. Anna BerounH-Index: 5
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The article describes different groups of psychoactive substances, which are chemical compounds that alter perception. Based on their main effect on the psyche they were classified into four subclasses: stimulants, empathogens, hallucinogens and depressants., Molecular mechanisms of action of different drugs of abuse were described, together with their social and economic issues in Poland and Europe.
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