Giornale italiano di dermatologia e venereologia : organo ufficiale, Società italiana di dermatologia e sifilografia
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#1Irene Lastrucci (UniFI: University of Florence)H-Index: 2
#2Vieri Grandi (UniFI: University of Florence)H-Index: 10
Last. Nicola Pimpinelli (UniFI: University of Florence)H-Index: 48
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Pemphigus vulgaris (PV) is an autoimmune blistering disease, in which autoantibodies against epidermal cadherins, such as desmoglein (Dsg)1 and Dsg3, lead to the development of blisters and erosions on the skin and mucous membranes. Autoreactive CD4+ T cells are essential for the induction and perpetuation of the disease by interaction with B cells producing autoantibodies. PV has a strong genetic association with certain human leucocyte antigen (HLA) alleles with HLA-DRB1*04:02 and LA-DQB1*05:0...
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#1Bruno GualtieriH-Index: 3
#2Angelo V. Marzano (University of Milan)H-Index: 44
Last. Sergei A. Grando (UCI: University of California, Irvine)H-Index: 70
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In this review, we recap current knowledge about non-desmoglein autoantigens in atypical forms of autoimmune pemphigus. More than 50 keratinocyte proteins, including adhesion molecules, receptors and enzymes as well as mitochondrial proteins can be targeted, leading to alterations in numerous intracellular signaling pathways. Patients with pemphigus herpetiformis feature various combinations of antibodies to desmogleins 1 and 3 and desmocollins 1-3. Pemphigus vulgaris patients who do not have an...
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#1Farzan Solimani (Humboldt University of Berlin)H-Index: 2
#2Katharina Meier (Humboldt University of Berlin)H-Index: 2
Last. Takashi Hashimoto (OCU: Osaka City University)H-Index: 83
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Pemphigus is a rare autoimmune blistering disease which manifests with painful erosions and blisters of the skin and mucosa. This disorder is caused by autoantibodies attacking desmosomal proteins, necessary for cell-cell contact stability and epidermal integrity. Desmoglein (Dsg) 1 and Dsg3 are the two major target antigens in pemphigus. Yet, many other target proteins, which have been described over the years, seem to be involved in the loss of epidermal integrity. Clinical examination, combin...
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#1Roberto Maglie (UniFI: University of Florence)H-Index: 10
#2Emiliano Antiga (UniFI: University of Florence)H-Index: 21
Last. Aimee S. Payne (UPenn: University of Pennsylvania)H-Index: 32
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Pemphigus is a rare autoimmune disease of the skin, characterized by autoantibodies targeting adhesion proteins of the epidermis, in particular desmoglein 3 and desmoglein 1, that cause the loss of cell-cell adhesion and the formation of intraepidermal blisters. Given that these autoantibodies are both necessary and sufficient for pemphigus to occur, the goal of pemphigus therapy is the elimination of autoreactive Bcells responsible for autoantibody production. Rituximab, an anti-CD20 monoclonal...
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#1Stefano Veraldi (University of Milan)H-Index: 23
#2Susanna Benardon (University of Milan)H-Index: 4
Last. Gianluca Nazzaro (University of Milan)H-Index: 9
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Originally described by Anhalt as paraneoplastic pemphigus in 1990, paraneoplastic autoimmune multiorgan syndrome (PAMS) is a potentially lethal blistering disease, characterized by polymorphous clinical features, including mucocutaneous erosions, blisters, lichenoid papules, and erythema. Several autoantibodies have been detected in serum of PAMS patients, including anti-plakins, anti-alpha-2-macroglobulin like 1, and anti-desmogleins autoantibodies. The mortality rate of PAMS is up to 50%. Thi...
2 CitationsSource
#1Giulia Odorici (University of Modena and Reggio Emilia)H-Index: 7
#2Alessia Paganelli (University of Modena and Reggio Emilia)H-Index: 8
Last. Andrea Conti (University of Modena and Reggio Emilia)H-Index: 21
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BACKGROUND: Psoriasis is a chronic, relapsing disease and most epidemiological studies include selected patients undergoing systemic therapies only. Epidemiological data suggest that psoriasis affects 2-3% of the general population, and that men and women are equally affected. The objective was to identify differences in gender for disease severity, patient characteristics and comorbidities in patients with moderate to severe psoriasis, independent of therapy. METHODS: A retrospective medical ch...
1 CitationsSource
#1Luca Provvidenziale (UNISI: University of Siena)H-Index: 2
#2Elisa Cinotti (UNISI: University of Siena)H-Index: 18
Last. Pietro Rubegni (UNISI: University of Siena)H-Index: 32
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