Current problems in dermatology
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#1Frank RippkeH-Index: 14
#2Enzo BerardescaH-Index: 54
Last. Teresa M WeberH-Index: 9
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: Maintenance of an acidic stratum corneum pH is a major component of the skin's protective system and creates a hostile environment for colonization with pathogenic microorganisms. This barrier can however be overcome on healthy and in particular on compromised skin. Mycosis, diaper/incontinence dermatitis and wound healing are examples of cases where microbial infection is promoted by the altered skin conditions or environment. Fungi have a complex system that senses ambient pH that leads to m...
18 CitationsSource
: Several studies have generally described the existence of differences of skin surface pH according to gender, age, and ethnicity, but these studies have reported inconsistent results, depending on anatomical sites, methods, and time of measurement. Overall, it could be summarized that female sex, younger age, and black skin have a lower skin pH compared to male sex, older age, and white skin.
6 CitationsSource
#1Christian SurberH-Index: 30
#2Philippe HumbertH-Index: 31
Last. Howard I. MaibachH-Index: 135
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Ninety years ago - in 1928, the term acid mantle was coined by the physicians Heinrich Schade and Alfred Marchionini in Kiel, Germany. A decade later Marchionini and several coworkers published 5 scientific communications in the Klinische Wochenschrift on “Der Sauremantel der Haut und Bakterienabwehr” (acid mantle and defense against bacteria). They described experimental detail, documented age- and body site as well as skin disease-dependent skin pH shifts, and discussed the significance of the...
8 CitationsSource
Virtually all therapeutic proteins (biologics) elicit an immune response with the consequent production of anti-drug antibodies (ADA). The majority of ADA to therapeutic monoclonal antibodies (mAbs) are directed against the antigen-binding site of the therapeutic mAb, and hence are neutralizing. This nature of the ADA response explains why fully human antibodies can still be highly immunogenic. The detection of ADA is technically challenging and all assays have limitations, namely a limited capa...
17 CitationsSource
#1Tamás Bíró (University of Debrecen)H-Index: 60
#2Attila Oláh (University of Debrecen)H-Index: 15
Last. Attila Gábor Szöllősi (University of Debrecen)H-Index: 11
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: Regulation of pH is one of the most complex mechanisms in human physiology. Indeed, the H+ ion concentration not only contributes to the establishment and maintenance of the body's homeostasis (by defining isohydria) but it also acts as an ionic, electric or osmotic driving force; provides optimum conditions for the proper functions of a plethora of molecules; behaves as an extra- and intracellular signaling system; exerts protective functions, and so on. The versatile role of pH requires deli...
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: During aging, the pH of the epidermis goes up and the calcium gradient goes down. Both have negative effects on the protective function of the epidermis and both are connected to each other as is discussed here. In the aging process, the pH rises from ∼5 to ∼5.5-6. The establishment of the skin pH is the joint effort of several independent factors including the activity of sodium-hydrogen antiporters and the presence of lactate, urocanic acid, free fatty acids and melanophores in the outermost...
5 CitationsSource
Psoriasis is a chronic autoimmune disease which affects millions of people worldwide. Not only can psoriasis itself be debilitating and significantly reduce an individual's quality of life, but it is also a risk factor for other systemic disorders, such as metabolic syndrome, cardiovascular disease, and malignancy. Tremendous strides were made in the treatment of psoriasis during the mid-to-late-20th century, including the emergence of topical corticosteroids and vitamin D analogs, methotrexate,...
10 CitationsSource
: The pH is an important physicochemical factor that plays a significant role in various metabolic, molecular and cell-regulating processes. In the epidermis, the pH affects the barrier function on different levels. In many dermatoses that come along with an impaired barrier, shifts in the pH can be observed, and this is a problem that definitely needs to be addressed by finding appropriate galenic formulas when prescribing barrier protective basic care. With this in mind, 66 cosmetic preparatio...
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: The visibility of a skin condition or dermatosis led to the reasonable assumption that the direct application of a therapeutic remedy to the target tissue holds many advantages. Through centuries, the nomenclature of topical preparations has proliferated and finally been moulded into the compulsory nomenclature of official compendia. In everyday life, many terms have been added and have complicated understanding and communication among and between healthcare professionals and laypersons. A lar...
8 CitationsSource
Several epidermal barrier functions, like skin barrier regeneration and antimicrobial response, are related to the acidic nature of the skin surface pH (ss-pH). However, the epidermal acidification is known to be fragile and it is commonly accepted that cosmetic products, especially soaps and skin cleansing products, can induce significant changes in ss-pH. As a consequence, epidermal barrier function and skin microflora are affected negatively. ss-pH even increases after a single washing proced...
8 CitationsSource
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