Cancer Genomics & Proteomics
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3.28
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640
Papers 720
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#1Yan Li (Fudan University)H-Index: 1
#2Daojian Xun (Fudan University)
Last. Sha Tian (Fudan University)
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Background/aim null Body fluids are considered to be a rich source of disease biomarkers. Proteins in many body fluids have potential clinical applications for disease diagnostic and prognostic purposes. The aim of this study was to establish an in-depth multi-body fluid proteome. null Materials and methods null Ten body fluids associated with 8 types of cancers collected from 23 patients involved in 19 common diseases underwent liquid chromatography tandem mass spectrometry (MS) analysis after ...
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#1Mohiuddin (Kanazawa University)H-Index: 2
#1M D Mohiuddin (Kanazawa University)
Last. Kazuo Kasahara (Kanazawa University)H-Index: 28
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BACKGROUND/AIM Cisplatin combined with pemetrexed disodium heptahydrate (pemetrexed) is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer. However, its growth-inhibitory effects on KRAS-dependent lung cancer as monotherapy and combination therapy are not well understood. The aim of this study was to compare the effects of cisplatin and pemetrexed on A549 cells as mono- and combination therapies and elucidate the underlying mechanisms. MATERIAL...
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#1Shotaro Kuramitsu (Kyushu University)H-Index: 3
#2Takaaki Masuda (Kyushu University)H-Index: 17
Last. Shuhei Ito (Kyushu University)H-Index: 18
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BACKGROUND/AIM Peritoneal dissemination (PD) occurs frequently in gastric cancer (GC) and is fatal. The interactions between tumor cells and stromal cells are critical for cancer progression. Our aim was to identify a novel PD-associated gene derived from stromal cells in GC. MATERIALS AND METHODS Among the candidate PD-associated genes identified in our previous study, we focused on spondin-2 (SPON2), an extracellular matrix-secreted protein. Clinicopathological and prognostic analyses of SPON2...
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#1Elise RowinskiH-Index: 2
#2Nicolas MagnéH-Index: 48
Last. Olivier TredanH-Index: 33
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BACKGROUND/AIM This study aimed to describe genomic alterations on squamous cell cervical and anal carcinomas. MATERIALS AND METHODS From 2013 to 2019, 3,269 patients were included in the molecular screening ProfiLER trial. Only patients with non-metastatic cervical or anal cancer, and those initially treated with radiotherapy in a curative intent were selected. Genetic analyses were performed by next generation sequencing (NGS). RESULTS Genomic alterations were observed in most patients: 5 pati...
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#1Yojiro Kotake (Kindai University)H-Index: 19
#2Natsumi Matsunaga (Kindai University)H-Index: 2
Last. Ryotaro Okada (Kindai University)
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Background/aim null The long noncoding RNA OIP5 antisense RNA 1 (OIP5-AS1) is overexpressed in various cancer types, such as lung cancer, hepatoblastoma and cervical cancer, and functions to accelerate cell proliferation, invasion and migration. Here, we investigated the roIe of OIP5-AS1 in cell-cycle progression of H1299 and A549 non-small cell lung cancer cells, and FaDu and CAL27 head and neck squamous cell carcinoma cells. null Materials and methods null The cells were transfected with small...
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#1Ulrich H. Weidle (Hoffmann-La Roche)H-Index: 36
#2Fabian Birzele (Hoffmann-La Roche)H-Index: 23
Last. Simon Auslaender (Hoffmann-La Roche)
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In addition to chemotherapy, targeted therapies have been approved for treatment of locally advanced and metastatic gastric cancer. The therapeutic benefit is significant but more durable responses and improvement of survival should be achieved. Therefore, the identification of new targets and new approaches for clinical treatment are of paramount importance. In this review, we searched the literature for down-regulated microRNAs which interfere with druggable targets and exhibit efficacy in pre...
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#1Ioannis Panagopoulos (Oslo University Hospital)H-Index: 61
#2Ludmila Gorunova (Oslo University Hospital)H-Index: 25
Last. Sverre Heim (Oslo University Hospital)H-Index: 80
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BACKGROUND/AIM Benign smooth-muscle tumors, leiomyomas, occur in nearly every organ but are most common in the uterus. Whereas much is known about the genetics of uterine leiomyomas, little genetic information exists about leiomyomas of other organs. Here, we report and discuss the genetic findings in a para-testicular leiomyoma. MATERIALS AND METHODS Cytogenetic, array comparative genomic hybridization (aCGH) RNA sequencing, reverse-transcription polymerase chain reaction (RT- PCR), and Sanger ...
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#1Young Un Choi (Yonsei University)H-Index: 4
#2Yongdae Yoon (Yonsei University)
Last. Young Woo Eom (Yonsei University)H-Index: 17
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Background/aim null Mesenchymal stem cell-based tumor therapy is still limited due to the insufficient secretion of effectors and discrepancies between their in vitro and in vivo efficacy. We investigated whether genetically engineered adipose tissue-derived mesenchymal stem cells (ASCs) overexpressing tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) had inhibitory effects on H460 tumor growth both in vitro and in an H460 xenograft model. null Materials and methods null Geneticall...
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#1Sivan Gershanov (Ariel University)H-Index: 5
#2Helen ToledanoH-Index: 15
Last. Mali Salmon-Divon (Ariel University)H-Index: 22
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BACKGROUND/AIM Germline mutations in PTCH1 or SUFU in the sonic hedgehog (SHH) pathway cause Gorlin's syndrome with increased risk of developing SHH-subgroup medulloblastoma. Gorlin's syndrome precludes the use of radiotherapy (a standard component of treatment) due to the development of multiple basal cell carcinomas. Also, current SHH inhibitors are ineffective against SUFU-mutated medulloblastoma, as they inhibit upstream genes. In this study, we aimed to detect differences in the expression ...
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#1Ulrich H. Weidle (Hoffmann-La Roche)H-Index: 36
#2Adam Nopora (Hoffmann-La Roche)H-Index: 11
In order to identify new targets and treatment modalities for clear cell renal carcinoma, we surveyed the literature with respect to microRNAs involved in this disease. In this review, we have focused on up- and down-regulated miRs which mediate efficacy in preclinical clear-cell renal carcinoma-related in vivo models. We have identified 10 up-regulated and 33 down-regulated micro-RNAs according to this criterion. As proof-of-concept, micro-RNAs interfering with VEGF (miR-205p) and mTOR (mir-99a...
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