Current Vascular Pharmacology
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#1Cristian Espinoza (UC: Pontifical Catholic University of Chile)
#2Barbara Fuenzalida (University of Bern)
Last. Andrea Leiva (San Sebastián University)
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Cardiovascular diseases (CVD) remain a major cause of death worldwide. Evidence suggests that the risk for CVD can increase at fetal stages due to maternal metabolic diseases such as gestational diabetes mellitus (GDM) and maternal supraphysiological hypercholesterolemia (MSPH). GDM is a hyperglycemic, inflammatory and insulin-resistant state that increases plasma levels of free fatty acids and triglycerides, impairs endothelial vascular tone regulation and, due to increased nutrient transport, ...
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#1Goran KoracevicH-Index: 8
#2Sladjana Micic (University of Niš)H-Index: 1
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BACKGROUND There is a need to analyse the current approach to beta-blocker (BB) use in relation to exercise-based stress tests. OBJECTIVE We compared various guidelines regarding recommending abrupt vs gradual discontinuation of BB prior to exercise tests. We also analyse the shortcomings of the currently recommended approach and suggest a new approach to avoid BB rebound. METHODS A narrative review is used to analyse this topic due to lack of valid randomized clinical trials. RESULTS Omitting t...
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Aging has been considered to be the most important non-modifiable risk factor for stroke and death. Changes in circulation factors in the systemic environment, cellular senescence and artery hypertension during human ageing have been investigated. Exosomes are nanosize membrane vesicles that can regulate target cell functions via delivering their carried bioactive molecules (e.g. protein, mRNA, and microRNAs). In the central nervous system, exosomes and exosomal microRNAs play a critical role in...
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#1Antonio SiniscalchiH-Index: 24
#2Roman SztajzelH-Index: 31
Last. Luca GallelliH-Index: 34
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#1Xia LiH-Index: 2
#2Dianxuan GuoH-Index: 2
Last. Ying ChenH-Index: 2
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BACKGROUND Pro-inflammatory mediators and oxidative stress are related to severity of angina pectoris in patients with coronary heart disease. OBJECTIVE We evaluated the effects of pro-inflammatory mediators and oxidative stress on recurrent angina pectoris after coronary artery stenting in elderly patients. METHODS We determined the expression levels of malondialdehyde (MDA), acrolein (ACR), tumour necrosis factor-α (TNF-α), toll-like receptor 4 (TLR4), superoxide dismutase 3 (SOD3), paraoxonas...
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#1Jiangping Gao (Chinese PLA General Hospital)
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BACKGROUND Thromboangiitis obliterans (TAO) is a chronic, non-atherosclerotic, progressive inflammatory vascular disease affecting the small- and medium-size arteries and veins of the extremities. OBJECTIVE To evaluate whether long-term anticoagulation with low-molecular-weight heparin (LMWH) and warfarin is beneficial for treating the inflammation and symptoms associated with TAO. METHODS Patients with TAO who underwent anticoagulation as the mainstay of treatment were included in this prospect...
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#1Jörn F. Dopheide (University of Bern)H-Index: 11
#2Luise Adam (University of Bern)H-Index: 5
Last. Heinz DrexelH-Index: 23
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BACKGROUND Patients with peripheral artery disease (PAD) fall under the category of a very high cardiovascular risk. Although, consequent lipid lowering therapy (LLT) is advised, only sparse data on attained target level in PAD exists. OBJECTIVES We aimed to analyse contemporary guideline recommendations for LLT in symptomatic PAD patients. METHODS monocentric, prospective, observational study involving 200 symptomatic PAD patients. Guideline target level attainment and LLT were analysed between...
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#1Xiaohan Xu (Capital Medical University)H-Index: 5
#2Meng Chai (Capital Medical University)H-Index: 5
Last. Yujie Zhou (Capital Medical University)H-Index: 23
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AIMS To explore early intensive lipid-lowering therapy in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). BACKGROUND Lowering low-density lipoprotein cholesterol (LDL-C) levels can reduce cardiovascular morbidity and mortality in patients with atherosclerotic cardiovascular disease. Due to many reasons, the need for early intensive lipid-lowering therapy is far from being met in Chinese NSTE-ACS patients at high-risk of recurrent ischaemic events. OBJECTIVE To evaluate...
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#1Agnieszka Dębska-Kozłowska (Medical University of Łódź)H-Index: 1
#2Izabela Warchoł (Medical University of Łódź)H-Index: 1
Last. Andrzej Lubiński (Medical University of Łódź)H-Index: 18
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BACKGROUND: Although cardiac resynchronisation therapy (CRT) is an important player in the treatment of heart failure (HF) patients, the proportion of CRT patients with no improvement in either echocardiographic or clinical parameters remains consistently high and accounts for about 30% despite meeting CRT implantation criteria. Furthermore, in patients suffering from HF, renal dysfunction accounts for as many as 30-60%. Accordingly, CRT may improve renal function inducing a systemic haemodynami...
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#1Zlatko Fras (Ljubljana University Medical Centre)H-Index: 19
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