International Journal of Toxicology
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#1Emmanuel Boulay (UdeM: Université de Montréal)H-Index: 4
#2Eric Troncy (UdeM: Université de Montréal)H-Index: 26
Last. Simon Authier (UdeM: Université de Montréal)H-Index: 4
view all 9 authors...
Respiratory monitoring, using impedance with implanted telemetry in socially housed animals, was not possible until the recent development of digital signal transmission. The objective of this study was to evaluate digital telemetry monitoring of cardiopulmonary parameters (respiratory rate, tidal volume, minute volume, electrocardiography (DII), systemic arterial blood pressure, physical activity, and body temperature) in conscious, single-housed, non-rodent species commonly used in toxicology ...
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#1Satoru Asami (Nihon University)H-Index: 11
#2Mikana Suzuki (Nihon University)
Last. Kenji Nishizawa (Toho University)H-Index: 3
view all 12 authors...
Research suggests that thioether analogs of vitamin K3 (VK3) can act to preserve the phosphorylation of epidermal growth factor receptors by blocking enzymes (phosphatases) responsible for their de...
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#1Christina L. Burnett (Cosmetic Ingredient Review)H-Index: 11
#2Wilma F. BergfeldH-Index: 22
Last. Paul W. SnyderH-Index: 16
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The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of inorganic hydroxides, which function in cosmetics primarily as pH adjusters. Representatives from the cosmetic industry have indicated these ingredients are used in depilating and hair waving/straightening formulations to raise pH values. The Panel considered relevant data related to these ingredients. The Panel concluded that these inorganic hydroxides are safe in hair straighteners and depilatories under conditions ...
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#1Simon Authier (Charles River Laboratories)H-Index: 4
#2William J. BrockH-Index: 7
Last. Michael K. PugsleyH-Index: 22
view all 8 authors...
The growth in drug development over the past years reflects significant advancements in basic sciences and a greater understanding of molecular pathways of disease. Benchmarking industry practices ...
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#1Stephanie Recillas-Román (UAM: Universidad Autónoma Metropolitana)
#2Martha MontañoH-Index: 23
Last. Carlos H.I. RamosH-Index: 36
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Wood smoke (WS) contains many harmful compounds, including polycyclic aromatic hydrocarbons (PAHs). WS induces inflammation in the airways and lungs and can lead to the development of various acute...
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The main considerations for the development of a formulation for preclinical safety assessment testing are explored. Intravenous, inhalation, oral and dermal dosing are given focus and although dif...
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#1Monice M. Fiume (Cosmetic Ingredient Review)H-Index: 12
#2Wilma F. BergfeldH-Index: 22
Last. Paul W. SnyderH-Index: 16
view all 12 authors...
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#1Christina L. Burnett (Cosmetic Ingredient Review)H-Index: 11
#2Wilma F. BergfeldH-Index: 22
Last. Paul W. SnyderH-Index: 16
view all 12 authors...
The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 8 keratin-derived ingredients, which function mainly as skin and hair conditioning agents in personal care products. The Panel reviewed relevant data provided in this safety assessment and concluded that the 8 keratin-derived ingredients are safe in the present practices of use and concentration described in this safety assessment.
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#1Laura N. Scott (Cosmetic Ingredient Review)
#2Wilma F. BergfeldH-Index: 22
Last. Paul W. SnyderH-Index: 16
view all 12 authors...
This is a safety assessment of 40 saccharide ester ingredients as used in cosmetics. The saccharide esters are reported to function in cosmetics as emollients, skin-conditioning agents, fragrance ingredients, and emulsion stabilizers. The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the relevant data for these ingredients. The Panel concluded that the saccharide esters are safe in cosmetics in the present practices of use and concentrations described in this safety assessment.
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#1Erik A. Larson (Charles River Laboratories)
#2Michael V. Accardi (Charles River Laboratories)H-Index: 5
Last. Simon Authier (UdeM: Université de Montréal)H-Index: 4
view all 5 authors...
A broad spectrum of chemical entities have been associated with drug-induced seizure (DIS), emphasizing the importance of this potential liability across various drug classes (e.g., antidepressants, antipsychotics, antibiotics, and analgesics among others). Despite its importance within drug safety testing, an understanding of the molecular mechanisms associated with DIS is often lacking. The etiology of DIS is understood to be a result of either a deficit in inhibitory (e.g., gamma aminobutyric...
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