European Journal of Endocrinology
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#1Barend W. Florijn (LUMC: Leiden University Medical Center)H-Index: 6
#2Jacques M.G.J. Duijs (LUMC: Leiden University Medical Center)H-Index: 16
Last. Maaike Hanegraaf (LUMC: Leiden University Medical Center)H-Index: 6
view all 18 authors...
Objective Sex steroid hormones like estrogens have a key role in the regulation of energy homeostasis and metabolism. In transwomen, gender-affirming hormone therapy like estradiol (in combination with antiandrogenic compounds) could affect metabolism as well. Given that the underlying pathophysiological mechanisms are not fully understood, this study assessed circulating estradiol-driven microRNAs (miRs) in transwomen and their regulation of genes involved in metabolism in mice. Methods Followi...
#6L. Cazabat (UVSQ: Versailles Saint-Quentin-en-Yvelines University)H-Index: 1
Objective Microprolactinomas are currently treated with dopamine agonists. Outcome information on microprolactinoma patients treated by surgery is limited. This study reports the first large series of consecutive non-invasive microprolactinoma patients treated by pituitary surgery and evaluates the efficiency and safety of this treatment. Design Follow-up of a cohort of consecutive patients treated by surgery. Methods Between January 2008 and October 2020, 114 adult patients with pure microprola...
#1Thierry BrueH-Index: 69
#2Sally A. Camper (UM: University of Michigan)H-Index: 79
Recent studies have shown a novel mechanism of combined pituitary hormone deficiency associated with mutations in POU1F1, altering the balance of alternative-splicing, which results in over-expression of the beta isoform of POU1F1. These studies underscore the need for biologists, in the context of the routine molecular diagnosis of this condition, to investigate alternative splicing in POU1F1 as well as in other genes.
#1Sara Storvall (UH: University of Helsinki)H-Index: 3
#2Helena Leijon (UH: University of Helsinki)H-Index: 7
Last. Johanna Arola (UH: University of Helsinki)H-Index: 49
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Objective Parathyroid carcinoma (PC), atypical parathyroid tumours (APT) and parathyroid adenoma (PA), all present with hypercalcemia. Diminished calcium-sensing receptor (CaSR) expression is reported in PC but is rare in benign tumours. Filamin A (FLNA) binds to the CaSR and activates the mitogen-activated protein kinase (MAPK) signalling pathway. FLNA is related to tumour aggressiveness in several cancers, but its role in parathyroid neoplasia is unknown. Design We examined FLNA, CaSR and para...
#2Malte P. Suppli (UCPH: University of Copenhagen)H-Index: 6
Last. Asger LundH-Index: 16
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In 2008, the first evidence of a new hormone called neuronostatin was published. The hormone was discovered using a bioinformatic method and found to originate from the same preprohormone as somatostatin. This small peptide hormone of 13 amino acids and a C-terminal amidation was soon found to exert pleiotropic physiological effects. In animal studies, neuronostatin has been shown to reduce food intake, and delay gastric emptying and gastrointestinal transit. Furthermore, neuronostatin has been ...
#1Tim Verweij (VU: VU University Amsterdam)
#2Tessa N. A. Slagboom (VU: VU University Amsterdam)H-Index: 1
Last. Christa C. van Bunderen (VU: VU University Amsterdam)H-Index: 1
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Context null Cardiovascular risk profile might differ between growth hormone treated patients with a craniopharyngioma and a non-functioning pituitary adenoma (NFPA), since patients with craniopharyngioma more frequently suffer from hypothalamic metabolic disruption. null Objective null The aim of this study is to investigate cardiovascular risk profile in adult patients with a craniopharyngioma compared to NFPA before and after treatment with growth hormone replacement therapy due to severe GH ...
Aims LMNA-linked familial partial lipodystrophy type 2 (FPLD2) leads to insulin resistance-associated metabolic complications and cardiovascular diseases. We aimed to characterise the disease phenotype in a cohort of patients carrying an LMNA founder variant. Methods We collected clinical and biological data from patients carrying the monoallelic or biallelic LMNA p.(Thr655Asnfs*49) variant (n = 65 and 13, respectively) and 19 non-affected relative controls followed-up in Reunion Island Lipodyst...
#1Lijuan Sun (Agency for Science, Technology and Research)H-Index: 7
#2Hui Jen GohH-Index: 7
Last. Pei Shan Yeo (NTU: Nanyang Technological University)
view all 21 authors...
OBJECTIVE Brown adipose tissue (BAT) controls metabolic rate through thermogenesis. As its regulatory factors during the transition from hyperthyroidism to euthyroidism are not well established, our study investigated the relationships between supraclavicular brown adipose tissue (sBAT) activity and physiological/metabolic changes with changes in thyroid status. DESIGN Participants with newly diagnosed Graves' disease were recruited. A thionamide anti-thyroid drug (ATD) such as carbimazole (CMZ)...
Top fields of study
Diabetes mellitus