Jennifer LeCouter
Genentech
Receptor tyrosine kinaseVascular endothelial growth factor CEndothelial stem cellEndocrinologyVascular endothelial growth factor AKinase insert domain receptorVascular endothelial growth inhibitorVascular endothelial growth factor BReceptorEndocrine glandEndotheliumVascular endothelial growth factorOvaryAngiogenesisPolycystic ovaryEndocrine systemCancer researchMedicineBiologyCell biology
25Publications
16H-index
10.3kCitations
Publications 18
Newest
#1Menno van Lookeren Campagne (Genentech)H-Index: 32
#2Jennifer LeCouter (Genentech)H-Index: 16
Last. Weilan Ye (Genentech)H-Index: 26
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As the age of the population increases in many nations, age-related degenerative diseases pose significant socioeconomic challenges. One of the key degenerative diseases that compromise quality of life is age-related macular degeneration (AMD). AMD is a multi-faceted condition that affects the central retina, which ultimately leads to blindness in millions of people worldwide. The pathophysiology and risk factors for AMD are complex, and the symptoms manifest in multiple related but distinct for...
184 CitationsSource
#1Lanlan Yu (Genentech)H-Index: 13
#2Xiumin Wu (Genentech)H-Index: 27
Last. Napoleone Ferrara (Genentech)H-Index: 156
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PURPOSE. Bevacizumab is a humanized anti-human VEGF-A monoclonal antibody (mAb) approved by the United States Food and Drug Administration for cancer therapy and used off label to treat neovascular age-related macular degeneration. Earlier studies characterized bevacizumab as species specific and lacking the ability to neutralize murine (m) VEGF-A. However, a recent study reported that bevacizumab is a potent inhibitor of hemangiogenesis and lymphangiogenesis in murine models. The authors sought...
268 CitationsSource
Bv8 and endocrine-gland-derived VEGF (EG-VEGF), or prokineticins, are two highly related, secreted proteins that we previously described as selective angiogenic mitogens. Here we describe the expression and functional characterization of Bv8 in peripheral blood cells, notably monocytes, neutrophils, and dendritic cells, and in the bone marrow. In human and mouse, the two Bv8 G protein-coupled receptors are expressed in hematopoietic stem cells and specific mature blood cells, including lymphocyt...
275 CitationsSource
#1Jennifer LeCouter (Genentech)H-Index: 16
#2Rui Lin (Genentech)H-Index: 7
Last. Napoleone Ferrara (Genentech)H-Index: 156
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: Angiogenesis is the focus of therapeutic efforts to promote new vessel development in damaged tissues. Conversely, inhibiting endothelial cell growth and survival is a strategy to treat various proliferative diseases. Much evidence indicates that VEGF is a key mediator of angiogenesis. Recently, a novel angiogenic mitogen with tissue-specific expression and target selectivity was characterized. Human endocrine gland derived vascular endothelial growth factor (EG-VEGF) is selectively expressed ...
21 CitationsSource
#1Napoleone Ferrara (Genentech)H-Index: 156
#2Jennifer LeCouter (Genentech)H-Index: 16
Last. Franklin Peale (Genentech)H-Index: 43
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A novel family of angiogenic mitogens have been recently characterized. Endocrine gland-derived vascular endothelial growth factor (EG-VEGF), and the mammalian homologue of Bombina variegata peptide 8 (Bv8), are two highly related endothelial cell mitogens and chemotactic factors with restricted expression profiles and selective endothelial cell activity. These peptides share two cognate G-protein coupled receptors. The expression of human EG-VEGF occurs predominantly in steroidogenic glands. Co...
90 CitationsSource
Abstract Angiogenic molecules are the focus of therapeutic efforts to promote new vessel development in ischemic or damaged tissue and, conversely, to inhibit endothelial cell growth and survival in proliferative disease. Two novel angiogenic mitogens have been characterized recently. Endocrine gland–derived vascular endothelial growth factor (EG-VEGF) and the mammalian homologue of Bombina variegata peptide 8 (Bv8) are endothelial cell mitogens and chemotactic factors with restricted expression...
67 CitationsSource
#1Jennifer LeCouter (Genentech)H-Index: 16
#2Rui Lin (Genentech)H-Index: 7
Last. Napoleone Ferrara (Genentech)H-Index: 156
view all 6 authors...
We recently described human endocrine gland-derived vascular endothelial growth factor (EG-VEGF) as an endothelial cell mitogen with a novel selective activity and an expression pattern essentially limited to steroidogenic glands. Herein we present the identification and characterization of the mouse ortholog. The mouse cDNA and predicted amino acid sequences are, respectively, 86% and 88% identical with the human. Surprisingly, the mouse EG-VEGF transcript is predominantly expressed in liver an...
73 CitationsSource
#1Napoleone Ferrara (Genentech)H-Index: 156
#2Gretchen Frantz (Genentech)H-Index: 34
Last. Franklin Peale (Genentech)H-Index: 43
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Angiogenesis is a key aspect of the dynamic changes occurring during the normal ovarian cycle. Hyperplasia and hypervascularity of the ovarian theca interna and stroma are also prominent features of the polycystic ovary syndrome (PCOS), a leading cause of infertility. Compelling evidence indicated that vascular endothelial growth factor (VEGF) is a key mediator of the cyclical corpus luteum angiogenesis. However, the nature of the factor(s) that mediate angiogenesis in PCOS is less clearly under...
239 CitationsSource
#1Napoleone Ferrara (Genentech)H-Index: 156
#2Hans-Peter Gerber (Genentech)H-Index: 55
Last. Jennifer LeCouter (Genentech)H-Index: 16
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Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. Non-signaling co-receptors also modulate VEGF R...
10.3k CitationsSource
We recently identified an angiogenic mitogen, endocrine-gland-derived vascular endothelial growth factor (EG-VEGF), with selective activity for endothelial cells of endocrine tissues. Here we describe the characterization of a highly related molecule, Bv8, also known as prokineticin-2. Human Bv8 shares 60% identity and 75% similarity with EG-VEGF. The human and mouse Bv8 genes share a common structure. Like EG-VEGF, Bv8 is able to induce proliferation, survival and migration of adrenal cortical ...
297 CitationsSource