Thiago Caon
Universidade Federal de Santa Catarina
CytotoxicityBiophysicsNuclear chemistryAbsorption (skin)SolubilityNanoparticleNanotechnologyBioavailabilityChemistryParticle sizeMaterials scienceBuccal administrationIn vitroIn vivoOral administrationAntioxidantChitosanDrug deliveryDrugComet assayChemical engineeringChromatographyPermeationPulmonary surfactantPlasticizerBiologyPharmacology
53Publications
14H-index
579Citations
Publications 54
Newest
#1Nicole E. Biondo (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
#2Débora Fretes Argenta (UFSC: Universidade Federal de Santa Catarina)H-Index: 3
Last. Thiago Caon (UFSC: Universidade Federal de Santa Catarina)H-Index: 14
view all 4 authors...
Abstract null null Cutaneous permeation assays are crucial to attest the performance or bioequivalence of topical or transdermal products. Although the official guidelines (e.g., FDA/EMA) play a key role in harmonizing the experimental design, alternative methods are often proposed by the scientific community, which makes it difficult to compare results from different studies. In this review, permeation assays with testosterone (TST) were selected to show this high variability in drug transport ...
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#1Mariana Alves Battisti (UFSC: Universidade Federal de Santa Catarina)H-Index: 3
#2Thiago Caon (UFSC: Universidade Federal de Santa Catarina)H-Index: 14
Last. Angela Machado de Campos (UFSC: Universidade Federal de Santa Catarina)H-Index: 10
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Abstract Although an antiviral, antibacterial, antimycobacterial and antifungal potential have been reported for the tea tree oil (TTO), low solubility, high volatility and oil oxidation may limit the formulation development step. In this context, micro- and nanoparticles could be considered to avoid these chemical instability problems. Furthermore, an improved efficacy could be found due to a greater surface area, which would increase the interactions between TTO and microorganisms. Overall, TT...
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In this study, three different combinations of essential oils (EO) of cinnamon, melaleuca and citronella were incorporated in polyhydroxybutyrate (PHB) films by conventional solution-casting method for food packaging applications. Although melaleuca and citronella EO films have been not demonstrated antimicrobial activity, they presented low UV transmission and high thermal stability. Films containing citronella and cinnamon EO or melaleuca and cinnamon EO, in turn, were active against all teste...
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#1Bibiana Silva (UFSC: Universidade Federal de Santa Catarina)H-Index: 5
#2Fabíola Carina Biluca (UFSC: Universidade Federal de Santa Catarina)H-Index: 7
Last. Ana Carolina Oliveira Costa (UFSC: Universidade Federal de Santa Catarina)H-Index: 26
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Abstract Honey is a natural ready-to-eat product rich in flavonoids, which is known by the wound healing properties due to both antibacterial and antioxidant activity. Flavonoids mitigate inflammatory processes, and thus it could currently support studies of anti-inflammatory potential of honeys. In this review, in vitro anti-inflammatory properties of flavonoids found in honey were prioritized. Mechanistic information of specific isolated flavonoids as modulators of inflammatory processes are s...
6 CitationsSource
#1Beatriz Ribeiro Amaral (UFSC: Universidade Federal de Santa Catarina)H-Index: 2
#2Rodrigo Henrique Saatkamp (UFSC: Universidade Federal de Santa Catarina)H-Index: 1
Last. Thiago Caon (UFSC: Universidade Federal de Santa Catarina)H-Index: 14
view all 9 authors...
Abstract Given that oral preparations of benznidazole (BZN) have demonstrated limited efficacy in the treatment of Chagas' disease due to pharmacokinetic or toxicological problems, the development of buccal polymeric films was purposed in this study. These systems ensure high patient acceptability and direct access to the systemic circulation, improving drug bioavailability and toxicological profile. Polymer films were prepared through a thermopressing method by mixing BZN and polyvinyl alcohol ...
2 CitationsSource
#1Débora Fretes Argenta (UFSC: Universidade Federal de Santa Catarina)H-Index: 3
#2Bianca da Costa Bernardo (UFSC: Universidade Federal de Santa Catarina)
Last. Thiago Caon (UFSC: Universidade Federal de Santa Catarina)H-Index: 14
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Abstract Secnidazole (SEC) has been suggested as an alternative agent against Trichomonas vaginalis to overcome the adverse effects, antimicrobial resistance problems and poor adherence to the currently available therapy. Once no topical formulation may be found in the market until now, SEC was incorporated in thermosensitive bioadhesive systems to extend the contact time in the mucosa and to avoid a systemic drug disposition. Formulations containing 20% poloxamer 407, 1% poloxamer 188 and 1 or ...
1 CitationsSource
#1Roselene Kroth (UFSC: Universidade Federal de Santa Catarina)H-Index: 2
#2Marcio Monteiro (UFSC: Universidade Federal de Santa Catarina)H-Index: 2
Last. Thiago Caon (UFSC: Universidade Federal de Santa Catarina)H-Index: 14
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Abstract In isolated isoniazid(INH)-resistant strains, deletion or mutations in the katG gene have been identified, which result in loss of catalase-peroxidase activity. This enzyme plays a key role in the activation of this prodrug. As an alternative, the coordination of the INH to metal complexes has been purposed to activate it regardless of enzyme functionality. Although pentacyanido(isoniazid)ferrate(II) complexes have shown to be effective against resistant strains of Mycobacterium tubercu...
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#1Adalberto Enumo (UFSC: Universidade Federal de Santa Catarina)H-Index: 3
#2Débora Fretes Argenta (UFSC: Universidade Federal de Santa Catarina)H-Index: 3
Last. Alexandre Luis Parize (UFSC: Universidade Federal de Santa Catarina)H-Index: 11
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The emergence of new materials with improved antibacterial, anti-inflammatory and healing properties compared to conventional wound dressings has both social and economic appeal. In this study, novel chitosan-based (CTS) membranes containing curcumin (CUR) incorporated in Pluronic (PLU) copolymers were developed and characterized to obtain suitable properties for applications as a wound healing dressing. The mechanical, thermal, swelling, wettability, release and permeation properties were evalu...
2 CitationsSource
#1Gabriela Schneider-Rauber (UFSC: Universidade Federal de Santa Catarina)
#2Débora Fretes Argenta (UFSC: Universidade Federal de Santa Catarina)H-Index: 3
Last. Thiago Caon (UFSC: Universidade Federal de Santa Catarina)H-Index: 14
view all 3 authors...
Dapsone (DAP) is a long-established molecule that remains a promising therapeutic agent for various diseases mainly because it combines antimicrobial and anti-inflammatory activities. Its oral application, however, is limited by the dose-dependent hematological side effects that may rise from systemic exposure. As an alternative to overcome this limitation, the administration of DAP to the skin has witnessed prominent interest in the past 20 years, particularly when applied to the treatment of d...
2 CitationsSource
#1Roselene Kroth (UFSC: Universidade Federal de Santa Catarina)H-Index: 2
#2Débora Fretes Argenta (UFSC: Universidade Federal de Santa Catarina)H-Index: 3
Last. Thiago Caon (UFSC: Universidade Federal de Santa Catarina)H-Index: 14
view all 5 authors...
The oral administration of isoniazid (INH) may lead to discontinuation of tuberculosis treatment due to drug-related hepatotoxicity events, and thus, the transbuccal delivery of this drug was investigated, for the first time, as an alternative administration route. Ex vivo permeability assays were performed in Franz-type diffusion chambers, applying INH alone and in combination with sodium dodecyl sulfate (SDS) and sodium taurocholate (ST). After confirming the formation of micelle structures by...
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