Valentina Appierto
University of Milan
PharmacokineticsCancerEndocrinologyOncologyApoptosisRetinoidNeoadjuvant therapyRetinolPrimary tumorOvarian cancerFenretinideCancer researchBreast cancerBiochemistryCell growthMedicineBiomarker (medicine)BiologyCell biologyCancer cell
41Publications
15H-index
723Citations
Publications 41
Newest
#1S. Di CosimoH-Index: 15
#2Valentina AppiertoH-Index: 15
Last. Maria Grazia DaidoneH-Index: 59
view all 12 authors...
1 CitationsSource
Circulating microRNA (ct-miRNAs) are able to identify patients with differential response to HER2-targeted therapy. However, their dynamics are largely unknown. We assessed 752 miRNAs from 52 NeoALTTO patients with plasma pairs prior and two weeks after trastuzumab. Increased levels of ct-miR-148a-3p and ct-miR-374a-5p were significantly associated with pathological complete response (pCR) (p = 0.008 and 0.048, respectively). At a threshold ≥ the upper limit of the 95%CI of the mean difference, ...
5 CitationsSource
#1Serena Di CosimoH-Index: 28
#2Valentina AppiertoH-Index: 15
Last. Matteo DugoH-Index: 19
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Triple negative breast cancer (TNBC) patients not attaining pathological Complete Response (pCR) after neo-adjuvant chemotherapy (NAC) have poor prognosis. We characterized 19 patients for somatic mutations in primary tumor biopsy and residual disease (RD) at surgery by 409 cancer-related gene sequencing (IonAmpliSeqTM Comprehensive Cancer Panel). A median of four (range 1–66) genes was mutated in each primary tumor biopsy, and the most common mutated gene was TP53 followed by a long tail of low...
4 CitationsSource
#1Serena Di CosimoH-Index: 28
#2Valentina AppiertoH-Index: 15
Last. Maria Grazia DaidoneH-Index: 59
view all 16 authors...
Purpose: To investigate the potential of circulating-microRNAs (ct-miRNAs) as non-invasive biomarkers to predict the efficacy of single/dual HER2-targeted therapy in the NeoALTTO study. Experimental Design: Patients with plasma samples at baseline (T0) and/or after two weeks (T1) of treatment were randomized into training (n=183) and testing (n=246) sets. RT-PCR-based high-throughput miRNA-profiling was employed in the training set. After normalization, ct-miRNAs associated with pathologic Compl...
11 CitationsSource
#1S. Di CosimoH-Index: 15
#2Valentina AppiertoH-Index: 15
Last. Maria Grazia DaidoneH-Index: 59
view all 10 authors...
Source
#1S. Di CosimoH-Index: 15
#2Valentina AppiertoH-Index: 15
Last. Maria Grazia DaidoneH-Index: 59
view all 20 authors...
Source
#2S. Di CosimoH-Index: 15
Last. Valentina AppiertoH-Index: 15
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1 CitationsSource
Abstract Breast cancer ranks first among female cancer-related deaths in Western countries. As the primary tumor can often be controlled by surgical resection, the survival of women with breast cancer is closely linked to the incidence of distant metastases. Molecular screening by next generation sequencing highlighted the spatial and temporal heterogeneity of solid tumors as well as the clonal evolution of cancer cells during progression and under treatment pressure. Such findings question whet...
24 CitationsSource
#1Paola TiberioH-Index: 11
#2Elena CavadiniH-Index: 18
Last. Valentina AppiertoH-Index: 15
view all 7 authors...
4-oxo-4-HPR, an active polar metabolite of the synthetic retinoid 4-HPR, was shown to exert promising antitumor activity through at least two independent mechanisms of action. Specifically, differently from 4-HPR and other retinoids, 4-oxo-4-HPR targets microtubules and inhibits tubulin polymerization causing mitotic arrest and on the other hand, analogously to the parent drug, it induces apoptosis through the activation of a signaling cascade involving the generation of reactive oxygen species....
4 CitationsSource
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