Jochen Zwerina
University of Erlangen-Nuremberg
Internal medicineEndocrinologyPathologyBone remodelingTumor necrosis factor alphaRheumatologyImmunologyOsteoclastInflammatory arthritisInflammationArthritisRheumatoid arthritisDiseaseRANKLFibrosisGranulomatosis with polyangiitisCancer researchBone resorptionMedicineCell biology
244Publications
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Publications 246
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#1Jakob E. SchandaH-Index: 5
#2Stephanie HuberH-Index: 1
Last. Roland Kocijan (Sigmund Freud University Vienna)H-Index: 9
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Abstract Background Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by impaired bone quality and quantity. Established imaging techniques have limited reliability in OI. The TX-Analyzer™ is a new, fractal-based software allowing a non-invasive assessment of bone structure based on conventional radiographs. We explored whether the TX-Analyzer™ can discriminate OI patients and healthy controls. Furthermore, we investigated the correlation between TX-Analyzer™ parameters and (...
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#1Moritz WeiglH-Index: 3
#2Roland Kocijan (Sigmund Freud University Vienna)H-Index: 1
Last. Matthias HacklH-Index: 26
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MicroRNAs regulate bone homeostasis and circulating microRNAs have been proposed as novel bone biomarkers. The effect of anti-osteoporotic treatment on circulating microRNAs has not been described in detail. Therefore, we performed a comprehensive analysis of microRNA serum levels in OVX and SHAM rats over 12 weeks of anti-resorptive or osteo-anabolic treatment. Forty-two Sprague Dawley rats underwent SHAM surgery (n=10) or ovariectomy (n=32). After 8 weeks, OVX rats were randomized to anti-reso...
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#1Roland KocijanH-Index: 15
#2Martina BehanovaH-Index: 5
Last. Jochen ZwerinaH-Index: 60
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Transiliac bone biopsy samples are used to evaluate histology and bone cell activity in unclear pathological conditions. However, much additional information can be obtained from such bone samples. Using the example of osteogenesis imperfecta (OI), the current article describes how biopsy samples can be further used to study bone material characteristics including the degree of matrix mineralization, organic matrix properties, mineral particle size and bone nanoporosity. OI is a heritable collag...
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#1Nadja Fratzl-Zelman (Sahlgrenska University Hospital)H-Index: 28
#2Katherine Wesseling-Perry (UCLA: University of California, Los Angeles)H-Index: 21
Last. Outi Mäkitie (Karolinska University Hospital)H-Index: 48
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Abstract Context Patients with osteoporosis-associated WNT1 or PLS3 mutations have unique bone histomorphometric features and osteocyte-specific hormone expression patterns. Objective To investigate the effects of WNT1 and PLS3 mutations on bone material properties. Design Transiliac bone biopsies were evaluated by quantitative backscattered electron imaging, immunohistochemistry, and bone histomorphometry. Setting Ambulatory patients. Patients Three pediatric and eight adult patients with WNT1 ...
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BACKGROUND Cirrhosis develops in <10% of individuals homozygous for the C282Y variant in the homeostatic iron regulator (HFE) gene. Carriage of PCSK7:rs236918 is associated with an increased risk of cirrhosis in this population. AIM To determine if genetic variants significantly associated with the risk of alcohol- and NAFLD-related cirrhosis also modulate the cirrhosis risk in C282Y homozygotes. METHODS Variants in PCSK7, PNPLA3, TM6SF2, MBOAT7 and HSD17B13 were genotyped in 1319 C282Y homozygo...
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#1Martina BehanovaH-Index: 5
#2Judith HaschkaH-Index: 15
Last. Roland KocijanH-Index: 15
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OBJECTIVE Patients with diabetes have an increased risk of osteoporosis and shorter life expectancy. Hip fracture (HF) is the most serious consequence of osteoporosis and is associated with increased mortality risk. We aimed to assess the association of antidiabetic medications with HF and the post-hip fracture mortality risk among diabetic patients ≥50 years. DESIGN In this nationwide case-control study 53,992 HF cases and 112,144 age-, sex- and region-matched non-hip fracture controls were ana...
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#1Roland KocijanH-Index: 15
#2Judith HaschkaH-Index: 15
Last. Jochen ZwerinaH-Index: 60
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In recent years, new treatment options for both common and rare bone diseases have become available. The sclerostin antibody romosozumab is the most recently approved drug for the therapy of postmenopausal osteoporosis. Its anabolic capacity makes it a promising treatment option for severe osteoporosis. Other sclerostin antibodies for the treatment of rare bone diseases such as osteogenesis imperfecta are currently being investigated. For rare bone diseases such as X‑linked hypophosphatemia (XLH...
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#1Judith HaschkaH-Index: 15
#2Daniel Arian KrausH-Index: 1
Last. Roland KocijanH-Index: 15
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Crohn’s disease (CD) is associated with bone loss and increased fracture risk. TX-Analyzer™ is a new fractal-based technique to evaluate bone microarchitecture based on conventional radiographs. The aim of the present study was to evaluate the TX-Analyzer™ of the thoracic and lumbar spine in CD patients and healthy controls (CO) and to correlate the parameters to standard imaging techniques. 39 CD patients and 39 age- and sex-matched CO were analyzed. Demographic parameters were comparable betwe...
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